L-Norleucine (BioCAD00000013099)
Metabolite Card
Chinese Name: L-正亮氨酸
Formula: C6H13NO2 (131.0946)
SMILES:
CCCC[C@H](N)C(O)=OSynonyms [en]
L-Norleucine; Norleucine; L-2-Aminohexanoate; L-Aminohexanoic acid; (S)-2-Aminohexanoic acid; L-2-Aminohexanoic acid
Last reviewed on 2026-04-16.
Cite this Page
L-Norleucine. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/L-Norleucine
(retrieved
2026-08-20) (CAD Registry RN: BioCAD00000013099). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
L-Norleucine, also known as L-aminohexanoate or caprine, belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. Thus, L-norleucine is considered to be a fatty acid lipid molecule. An unnatural amino acid that is used experimentally to study protein structure and function. L-Norleucine is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. L-Norleucine exists in all eukaryotes, ranging from yeast to humans. Outside of the human body, L-Norleucine has been detected, but not quantified in cow milk. This could make L-norleucine a potential biomarker for the consumption of these foods. It binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin.
DBLinks
- CAS Registry Number: 327-57-1
- PubChem CID: 21236
- ChEBI: 18347
- HMDB: HMDB0001645
- LipidMaps: LMFA01100042
- KEGG: C01933
- BioCyc: L-2-AMINOHEXANOATE
- NCBI MeSH: Norleucine
- Wikipedia: Norleucine
Other DBLinks
- CAS Registry Number: 327-57-1
- CAS Registry Number: 496-90-2
- PubChem: 21236
- PubChem: 5038
- PubChem: 9475
- ChEBI: ChEBI:18347
- ChEBI: ChEBI:21203
- ChEBI: ChEBI:58455
- HMDB: HMDB0001645
- HMDB: HMDB01645
- LipidMaps: LMFA01100042
- KEGG: C01933
- BioCyc: L-2-AMINOHEXANOATE
- NCBI MeSH: Norleucine
- Wikipedia: Norleucine
- DrugBank: DB04419
- DrugBank: DB15458
- RefMet: RM0134973
- MoNA: BAF_UVA_POS000139
- MoNA: BAF_UVA_POS000140
- MoNA: BAF_UVA_POS000141
- MoNA: BAF_UVA_POS001170
- MoNA: CCMSLIB00000479722
- MoNA: CCMSLIB00000578028
- MoNA: CCMSLIB00000578271
- MoNA: CCMSLIB00005463970
- MoNA: CCMSLIB00005463987
- MoNA: CCMSLIB00005720468
- MoNA: CCMSLIB00005720761
- MoNA: EMBL-MCF_spec59716
- MoNA: EMBL-MCF_spec59722
- MoNA: FiehnHILIC000621
- MoNA: FiehnHILIC001403
- MoNA: FiehnHILIC002189
- MoNA: FiehnHILIC002888
- MoNA: FiehnLib000421
- MoNA: FiehnLib000422
- MoNA: GLS00050
- MoNA: GLS00052
- MoNA: HMDB0001645_c_ms_1049
- MoNA: HMDB0001645_c_ms_1239
- MoNA: HMDB0001645_c_ms_958
- MoNA: HMDB0001645_ms_ms_1669
- MoNA: HMDB0001645_ms_ms_1670
- MoNA: HMDB0001645_ms_ms_1671
- MoNA: KO001520
- MoNA: KO001521
- MoNA: KO001522
- MoNA: KO003597
- MoNA: KO003598
- MoNA: KO003599
- MoNA: KO003600
- MoNA: KO003601
- MoNA: KZ000051
- MoNA: KZ000160
- MoNA: MoNA002067
- MoNA: MoNA002068
- MoNA: MoNA002069
- MoNA: MoNA024003
- MoNA: MoNA024010
- MoNA: MoNA032216
- MoNA: MoNA032220
- MoNA: MoNA032222
- MoNA: MoNA034180
- MoNA: MoNA034183
- MoNA: MoNA034185
- MoNA: MoNA035864
- MoNA: MoNA035867
- MoNA: MoNA035869
- MoNA: MoNA036129
- MoNA: MoNA036131
- MoNA: MoNA036132
- MoNA: MoNA037210
- MoNA: MoNA037920
- MoNA: MoNA038586
- MoNA: MoNA_0006378
- MoNA: MoNA_0006379
- MoNA: MoNA_0006380
- MoNA: MoNA_0006381
- MoNA: MoNA_0006382
- MoNA: MoNA_0006383
- MoNA: MoNA_0007494
- MoNA: MoNA_0007497
- MoNA: MoNA_0007498
- MoNA: MoNA_0007499
- MoNA: MoNA_0007501
- MoNA: MoNA_0007502
- MoNA: MoNA_0007945
- MoNA: MoNA_0008199
- MoNA: MoNA_0008200
- MoNA: OUF00393
- MoNA: PR010064
- MoNA: PR100169
- MoNA: PR100170
- MoNA: PR100583
- MoNA: PS028301
- MoNA: PS028302
- MoNA: PS028303
- MoNA: PS028304
- MoNA: PT102830
- MoNA: PT102833
- MoNA: PT202830
- MoNA: RP002201
- MoNA: RP002202
- MoNA: RP002203
- MoNA: RP002211
- Metlin: METLIN_6334
- Coconut NaturalProduct: CNP0177876.1
- metaboanalyst: 4d13fc7cd725943c50f1609324b488be
- metaboanalyst: 50dcec84a793be6bbed69c3d74d510c1
- metaboanalyst: 7eab1d3997bed455332a25920a8bb27f
- metaboanalyst: 8a276549dd87b7dda6b224562352b6ab
- metaboanalyst: a8718440cb6399680b8c74d004976384
- metaboanalyst: f0615b2a928fe19daff00e2b439ba47b
Class / Ontology
- WishartLab ClassyFire: [Amino acids, peptides, and analogues] Amino acids, peptides, and analogues
- RefMet: [Amino acids] Amino acids
- LipidMaps: [Amino fatty acids [FA0110]] Amino fatty acids [FA0110]
- ChEBI: [CHEBI:18347] L-norleucine
- Coconut NaturalProduct: [Amino fatty acids] Amino fatty acids
| ID | EC Number | Name |
|---|---|---|
| KEGG:R03053 | 2.6.1.67 | L-2-aminohexanoate:2-oxoglutarate aminotransferase |
| BioCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN | 2.6.1.67 | 2-KETOGLUTARATE + L-2-AMINOHEXANOATE<=>GLT + 2-OXOHEXANOATE |