Dihydrofolate (BioCAD00000010047)

blood liver plant natural products

Metabolite Card

Chinese Name: 二氢叶酸
Formula: C19H21N7O6 (443.1553)
SMILES: 

NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1

Synonyms [en]

dihydrofolate; Dihydrofolic acid; 7,8-dihydrofolate; 7,8-Dihydropteroylglutamate; 7,8-dihydrofolic acid; N-(4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid

Reviewed

Last reviewed on 2026-04-16.

Cite this Page

Dihydrofolate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/Dihydrofolate (retrieved 2026-08-20) (CAD Registry RN: BioCAD00000010047). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. It interacts with bacteria during cell division. It can be targeted with drug analogs to prevent nucleic acid synthesis. Dihydrofolic acid is also known by the name Dihydrofolate - more commonly Vitamin B9.

Extracellular Mitochondria Lysosome
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 4033-27-6
  • PubChem: 135398604
  • PubChem: 98792
  • ChEBI: ChEBI:15633
  • HMDB: HMDB0001056
  • KEGG: C00415
  • BioCyc: THF
  • NCBI MeSH: dihydrofolate
  • Wikipedia: Dihydrofolic acid
  • Wikipedia: Dihydrofolic_acid
  • DrugBank: DB02015
  • RefMet: RM0136037
  • MoNA: BAF_UVA_POS000397
  • MoNA: BAF_UVA_POS001275
  • MoNA: CCMSLIB00005720334
  • MoNA: EMBL-MCF_spec209348
  • Metlin: METLIN_3537
  • Coconut NaturalProduct: CNP0251838.1
  • Coconut NaturalProduct: CNP0335388.1
  • Coconut NaturalProduct: CNP0600224.1
  • Coconut NaturalProduct: CNP0606214.0
  • metaboanalyst: 3d956b36769af3264d4a3615d04eeef3
  • metaboanalyst: d9e5969c5b874ed417faa4a0b2989138
  • metaboanalyst: f5dd47e2de5be2952dfa31819df5c2ca

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R00936 1.5.1.3 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
KEGG:R00939 1.5.1.3 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
KEGG:R01670 2.1.1.54 5,10-methylenetetrahydrofolate:dCMP C-methyltransferase
KEGG:R02101 2.1.1.45 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
KEGG:R02235 1.5.1.3 dihydrofolate:NAD+ oxidoreductase
KEGG:R02236 1.5.1.3 dihydrofolate:NADP+ oxidoreductase
KEGG:R02237 6.3.2.12 7,8-dihydropteroate:L-glutamate ligase (ADP-forming)
KEGG:R02238 6.3.4.17 formate:dihydrofolate ligase (ADP-forming)
BioCyc:RXN-19329 1.5.1.3 DIHYDROFOLATE + NADPH + PROTON --> THF + NADP
BioCyc:RXN-3741 3.4.19.9 Folatepolyglutamate(n)
View More
Mass Spectrum
匿名访客 · 受限内容

内容已锁定

您当前以匿名访客身份浏览，此页面的内容由作者限定为已登录用户可见。
请使用您的邮箱登录后继续查看。

使用邮箱继续

首次使用将自动为您创建账户。
遇到问题？查看登录帮助



View All Mass Spectrum
Organism Source

Taxonomy Source

  1. Arabidopsis thaliana [ncbi taxid: 3702]
  2. Escherichia coli [ncbi taxid: 562]
  3. Escherichia coli [ncbi taxid: 562]
  4. Homo sapiens [ncbi taxid: 9606]
  5. Mus musculus [ncbi taxid: 10090]

Pathway Synthetic

pathway id name
BioCyc:SMAN_1CMET2-PWY formylTHF biosynthesis I
BioCyc:PCHR_PWY-3841 formylTHF biosynthesis II
BioCyc:PCHR_1CMET2-PWY formylTHF biosynthesis I
BioCyc:PCHR_PWY-3742 tetrahydrofolate biosynthesis II
BioCyc:PCHR_FOLSYN-PWY tetrahydrofolate biosynthesis
PathBank:SMP0000959 Pyrimidine Metabolism
PathBank:SMP0001750 One Carbon Pool by Folate
PathBank:SMP0120678 beta-Ureidopropionase Deficiency
PathBank:SMP0120742 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0120750 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
PathBank:SMP0121324 Pyrimidine Metabolism
PathBank:SMP0122040 One Carbon Pool by Folate
PathBank:SMP0000178 Dihydropyrimidinase Deficiency
PathBank:SMP0000432 Methotrexate Action Pathway
PathBank:SMP0002369 One Carbon Pool by Folate I
PathBank:SMP0120693 Dihydropyrimidinase Deficiency
PathBank:SMP0120507 UMP Synthase Deficiency (Orotic Aciduria)
PathBank:SMP0000046 Pyrimidine Metabolism
PathBank:SMP0000219 UMP Synthase Deficiency (Orotic Aciduria)
PathBank:SMP0000543 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
View All Pathways