EC: 2.7.7.12

UDP-glucose-hexose-1-phosphate uridylyltransferase (UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase)

enzyme lambda metabolic reaction experiment
uniprot:P07902 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) mutant E220K]

UDP_D_glucose + alpha_D_Galactose_1_phosphate -> alpha_D_Glucose_1_phosphate + UDP_D_galactose
(( (Vmax * S) ) / (S + Km)) buffer: 100 mM Glycine, 5 mM MgCl2 , 5 mM dithiothreitol, 0.8 mM NADP, 5 μM glucose-alpha-1,6-diphosphate, 0.5 U/ml Phosphoglucomutase, 0.5 U/ml Glucose-6-phosphate dehydrogenase
PH: 8.7
Temperature: 36
uniprot:P07902 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) mutant R201C]

alpha_D_Galactose_1_phosphate + UDP_D_glucose -> UDP_D_galactose + alpha_D_Glucose_1_phosphate
(( (Vmax * S) ) / (S + Km)) buffer: 100 mM Glycine, 5 mM MgCl2 , 5 mM dithiothreitol, 0.8 mM NADP, 5 μM glucose-alpha-1,6-diphosphate, 0.5 U/ml Phosphoglucomutase, 0.5 U/ml Glucose-6-phosphate dehydrogenase
PH: 8.7
Temperature: 36
uniprot:P07902 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) wildtype]

alpha_D_Galactose_1_phosphate + UDP_D_glucose -> alpha_D_Glucose_1_phosphate + UDP_D_galactose
(( (Vmax * S) ) / (S + Km)) buffer: 100 mM Glycine, 5 mM MgCl2 , 5 mM dithiothreitol, 0.8 mM NADP, 5 μM glucose-alpha-1,6-diphosphate, 0.5 U/ml Phosphoglucomutase, 0.5 U/ml Glucose-6-phosphate dehydrogenase
PH: 8.7
Temperature: 36
uniprot:P07902 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) wildtype]

alpha_D_Galactose_1_phosphate + UDP_D_glucose -> alpha_D_Glucose_1_phosphate + UDP_D_galactose
(( (Vmax * S) ) / (S + Km)) buffer: 100 mM Glycine, 5 mM MgCl2 , 5 mM dithiothreitol, 0.8 mM NADP, 5 μM glucose-alpha-1,6-diphosphate, 0.5 U/ml Phosphoglucomutase, 0.5 U/ml Glucose-6-phosphate dehydrogenase
PH: 8.7
Temperature: 36
uniprot:P07902 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) mutant R201C]

UDP_D_glucose + alpha_D_Galactose_1_phosphate -> alpha_D_Glucose_1_phosphate + UDP_D_galactose
(( (Vmax * S) ) / (S + Km)) buffer: 100 mM Glycine, 5 mM MgCl2 , 5 mM dithiothreitol, 0.8 mM NADP, 5 μM glucose-alpha-1,6-diphosphate, 0.5 U/ml Phosphoglucomutase, 0.5 U/ml Glucose-6-phosphate dehydrogenase
PH: 8.7
Temperature: 36
uniprot:P07902 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) mutant E220K]

alpha_D_Galactose_1_phosphate + UDP_D_glucose -> UDP_D_galactose + alpha_D_Glucose_1_phosphate
(( (Vmax * S) ) / (S + Km)) buffer: 100 mM Glycine, 5 mM MgCl2 , 5 mM dithiothreitol, 0.8 mM NADP, 5 μM glucose-alpha-1,6-diphosphate, 0.5 U/ml Phosphoglucomutase, 0.5 U/ml Glucose-6-phosphate dehydrogenase
PH: 8.7
Temperature: 36
uniprot:P07902 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) mutant E291V]

UDP_D_glucose + alpha_D_Galactose_1_phosphate -> alpha_D_Glucose_1_phosphate + UDP_D_galactose
(( (Vmax * S) ) / (S + Km)) buffer: 100 mM Glycine, 5 mM MgCl2 , 5 mM dithiothreitol, 0.8 mM NADP, 5 μM glucose-alpha-1,6-diphosphate, 0.5 U/ml Phosphoglucomutase, 0.5 U/ml Glucose-6-phosphate dehydrogenase
PH: 8.7
Temperature: 36
uniprot:P07902 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) mutant R223S]

UDP_D_glucose + alpha_D_Galactose_1_phosphate -> UDP_D_galactose + alpha_D_Glucose_1_phosphate
(( (Vmax * S) ) / (S + Km)) buffer: 100 mM Glycine, 5 mM MgCl2 , 5 mM dithiothreitol, 0.8 mM NADP, 5 μM glucose-alpha-1,6-diphosphate, 0.5 U/ml Phosphoglucomutase, 0.5 U/ml Glucose-6-phosphate dehydrogenase
PH: 8.7
Temperature: 36
uniprot:P07902 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) mutant E291V]

alpha_D_Galactose_1_phosphate + UDP_D_glucose -> alpha_D_Glucose_1_phosphate + UDP_D_galactose
(( (Vmax * S) ) / (S + Km)) buffer: 100 mM Glycine, 5 mM MgCl2 , 5 mM dithiothreitol, 0.8 mM NADP, 5 μM glucose-alpha-1,6-diphosphate, 0.5 U/ml Phosphoglucomutase, 0.5 U/ml Glucose-6-phosphate dehydrogenase
PH: 8.7
Temperature: 36
uniprot:P07902 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) mutant I278N]

alpha_D_Galactose_1_phosphate + UDP_D_glucose -> alpha_D_Glucose_1_phosphate + UDP_D_galactose
(( (Vmax * S) ) / (S + Km)) buffer: 100 mM Glycine, 5 mM MgCl2 , 5 mM dithiothreitol, 0.8 mM NADP, 5 μM glucose-alpha-1,6-diphosphate, 0.5 U/ml Phosphoglucomutase, 0.5 U/ml Glucose-6-phosphate dehydrogenase
PH: 8.7
Temperature: 36
uniprot:P07902 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) mutant L289F]

alpha_D_Galactose_1_phosphate + UDP_D_glucose -> alpha_D_Glucose_1_phosphate + UDP_D_galactose
(( (Vmax * S) ) / (S + Km)) buffer: 100 mM Glycine, 5 mM MgCl2 , 5 mM dithiothreitol, 0.8 mM NADP, 5 μM glucose-alpha-1,6-diphosphate, 0.5 U/ml Phosphoglucomutase, 0.5 U/ml Glucose-6-phosphate dehydrogenase
PH: 8.7
Temperature: 36
uniprot:P07902 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) mutant I278N]

alpha_D_Galactose_1_phosphate + UDP_D_glucose -> alpha_D_Glucose_1_phosphate + UDP_D_galactose
(( (Vmax * S) ) / (S + Km)) buffer: 100 mM Glycine, 5 mM MgCl2 , 5 mM dithiothreitol, 0.8 mM NADP, 5 μM glucose-alpha-1,6-diphosphate, 0.5 U/ml Phosphoglucomutase, 0.5 U/ml Glucose-6-phosphate dehydrogenase
PH: 8.7
Temperature: 36
uniprot:P07902 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) mutant L289F]

UDP_D_glucose + alpha_D_Galactose_1_phosphate -> UDP_D_galactose + alpha_D_Glucose_1_phosphate
(( (Vmax * S) ) / (S + Km)) buffer: 100 mM Glycine, 5 mM MgCl2 , 5 mM dithiothreitol, 0.8 mM NADP, 5 μM glucose-alpha-1,6-diphosphate, 0.5 U/ml Phosphoglucomutase, 0.5 U/ml Glucose-6-phosphate dehydrogenase
PH: 8.7
Temperature: 36
uniprot:P07902 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) mutant R223S]

alpha_D_Galactose_1_phosphate + UDP_D_glucose -> alpha_D_Glucose_1_phosphate + UDP_D_galactose
(( (Vmax * S) ) / (S + Km)) buffer: 100 mM Glycine, 5 mM MgCl2 , 5 mM dithiothreitol, 0.8 mM NADP, 5 μM glucose-alpha-1,6-diphosphate, 0.5 U/ml Phosphoglucomutase, 0.5 U/ml Glucose-6-phosphate dehydrogenase
PH: 8.7
Temperature: 36
uniprot:P09148 [Fe2+]

alpha_D_Galactose_1_phosphate + UDPglucose -> D_Glucose_1_phosphate + UDPgalactose
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (Ka * B) ) + (Kb * A)) ) + (A * B))) buffer: 95 mM sodium bicinate, 8 mM cysteine, 0.326 mM TPN+, 3.3 µM glucose-1,6-diphosphate, phosphoglucomutase, glucose-6-phosphate dehydrogenase, 10 mM beta-mercaptoethanol
PH: 8.5
Temperature: 27
uniprot:P09148 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) wildtype]

alpha_D_Glucose_1_phosphate + UDP_D_galactose -> alpha_D_Galactose_1_phosphate + UDP_D_glucose
(1 / (( (( (1 / V) ) * (( (1 + (Km_A / A)) ) + (( (( (Km_A * Q) ) / Ki_Q) ) * A))) ) + (( (Km_B / V) ) + (( (( (( (( (Km_A * Ki_B) ) * Q) ) / V) ) * Ki_Q) ) * A)))) buffer: 95 mM sodium bicinate, 8 mM cysteine
PH: 8.5
Temperature: 27
uniprot:P09148 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) wildtype]

alpha_D_Glucose_1_phosphate + UDP_D_galactose -> UDP_D_glucose + alpha_D_Galactose_1_phosphate
(1 / (( (( (1 / V) ) * (1 + (Km_A / A))) ) + (( (( (( (Km_B / V) ) * (( (1 + (P / Ki_P)) ) + (( (( (Ki_A * P) ) / Ki_P) ) * A))) ) * 1) ) / B))) buffer: 95 mM sodium bicinate, 8 mM cysteine, 0.382 mM NAD+, excess UDP-glucose dehydrogenase
PH: 8.5
Temperature: 27
uniprot:P09148 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) wildtype]

UDP_D_glucose + alpha_D_Galactose_1_phosphate -> UDP_D_galactose + alpha_D_Glucose_1_phosphate
(1 / (( (( (1 / V) ) + (( (Km_B / V) ) * B)) ) + (( (( (Km_A / V) ) * A) ) * (1 + (B / KI_B))))) buffer: 95 mM sodium bicinate, 8 mM cysteine
PH: 8.5
Temperature: 27
uniprot:P09148 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) wildtype]

alpha_D_Glucose_1_phosphate + UDP_D_galactose -> UDP_D_glucose + alpha_D_Galactose_1_phosphate
(( (( (Vmax * A) ) * B) ) / (( (( (Km_A * B) ) + (Km_B * A)) ) + (A * B))) buffer: 95 mM sodium bicinate, 8 mM cysteine, 0.382 mM NAD+, excess UDP-glucose dehydrogenase
PH: 8.5
Temperature: 27
uniprot:P09148 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) wildtype]

UDP_D_glucose + alpha_D_Galactose_1_phosphate -> UDP_D_galactose + alpha_D_Glucose_1_phosphate
(( (( (Vmax * A) ) * B) ) / (( (( (Km_A * B) ) + (Km_B * A)) ) + (A * B))) buffer: 95 mM sodium bicinate, 8 mM cysteine, 0.326 mM NADP+, 3.3 µM glucose-1,6-P2, excess phosphoglucomutase, excess glucose-6-P dehydrogenase
PH: 8.5
Temperature: 27
uniprot:P09148 [Fe2+]

UDPglucose + alpha_D_Galactose_1_phosphate -> UDPgalactose + D_Glucose_1_phosphate
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (Ka * B) ) + (Kb * A)) ) + (A * B))) buffer: 95 mM sodium bicinate, 8 mM cysteine, 0.326 mM TPN+, 3.3 µM glucose-1,6-diphosphate, phosphoglucomutase, glucose-6-phosphate dehydrogenase, 10 mM beta-mercaptoethanol
PH: 8.5
Temperature: 27
uniprot:P09148 [Fe2+]

alpha_D_Galactose_1_phosphate + UDPglucose -> D_Glucose_1_phosphate + UDPgalactose
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (Ka * B) ) + (Kb * A)) ) + (A * B))) buffer: 95 mM sodium bicinate, 8 mM cysteine, 0.326 mM TPN+, 3.3 µM glucose-1,6-diphosphate, phosphoglucomutase, glucose-6-phosphate dehydrogenase, 10 mM beta-mercaptoethanol
PH: 8.5
Temperature: 4
uniprot:P09148 [Fe2+]

D_Glucose_1_phosphate + UDPgalactose -> UDPglucose + alpha_D_Galactose_1_phosphate
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (Ka * B) ) + (Kb * A)) ) + (A * B))) buffer: 95 mM sodium bicinate, 8 mM cysteine, 0.382 mM DPN+, UDPglucose dehydrogenase, 10 mM beta-mercaptoethanol
PH: 8.5
Temperature: 27
uniprot:P09148 [Fe2+]

D_Glucose_1_phosphate + UDPgalactose -> alpha_D_Galactose_1_phosphate + UDPglucose
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (Ka * B) ) + (Kb * A)) ) + (A * B))) buffer: 95 mM sodium bicinate, 8 mM cysteine, 0.382 mM DPN+, UDPglucose dehydrogenase, 10 mM beta-mercaptoethanol
PH: 8.5
Temperature: 27
uniprot:P09148 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) wildtype]

UDPglucose + alpha_D_Galactose_1_phosphate -> D_Glucose_1_phosphate + UDPgalactose
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 83.33 mM Glycine-NaOH, 5 mM NaF, 14.5 mM Cysteine
PH: 8.5
Temperature: 25
uniprot:P09148 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) wildtype]

alpha_D_Galactose_1_phosphate + UDPglucose -> UDPgalactose + D_Glucose_1_phosphate
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 83.33 mM Glycine-NaOH, 5 mM NaF, 14.5 mM Cysteine
PH: 8.5
Temperature: 25
uniprot:P09148 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) wildtype]

alpha_D_Galactose_1_phosphate + UDPglucose -> UDPgalactose + D_Glucose_1_phosphate
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 83.33 mM Glycine-NaOH, 5 mM NaF, 14.5 mM Cysteine
PH: 8.5
Temperature: 25
uniprot:P09148 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) wildtype]

D_Glucose_1_phosphate + UDPgalactose -> alpha_D_Galactose_1_phosphate + UDPglucose
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 58 mM 2-Amino-2-methyl-1,3-propanediol, 0.48 mM NAD+, 25.8 mM Cysteine, 0.048 units/ml UDP-glucose dehydrogenase
PH: 8.5
Temperature: 27
uniprot:P09148 [UDP-glucose---hexose-1-phosphate uridylyltransferase(Enzyme) wildtype]

D_Glucose_1_phosphate + UDPgalactose -> UDPglucose + alpha_D_Galactose_1_phosphate
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 58 mM 2-Amino-2-methyl-1,3-propanediol, 0.48 mM NAD+, 25.8 mM Cysteine, 0.048 units/ml UDP-glucose dehydrogenase
PH: 8.5
Temperature: 25

Pathways

pathway id name
BioCyc:META_PWY66-422 D-galactose degradation V (Leloir pathway)
BioCyc:META_PWY-6317 D-galactose degradation I (Leloir pathway)
BioCyc:MOUSE_PWY-6317 galactose degradation I (Leloir pathway)
BioCyc:BSUB_PWY-6317 D-galactose degradation I (Leloir pathway)
BioCyc:ECOL316407_GALACTMETAB-PWY galactose degradation I (Leloir pathway)
BioCyc:HUMAN_PWY66-422 D-galactose degradation V (Leloir pathway)
BioCyc:YEAST_PWY66-422 D-galactose degradation V (Leloir pathway)
BioCyc:MOUSE_PWY3DJ-193 Leloir pathway
BioCyc:MOUSE_COLANSYN-PWY colanic acid building blocks biosynthesis
BioCyc:MOUSE_GALACTMETAB-PWY UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)
BioCyc:ECO_GALACTMETAB-PWY galactose degradation I (Leloir pathway)
PathBank:SMP0000841 Galactose Metabolism
PathBank:SMP0000903 Galactose Degradation/Leloir Pathway
PathBank:SMP0000906 Amino Sugar and Nucleotide Sugar Metabolism II
PathBank:SMP0000914 Amino Sugar and Nucleotide Sugar Metabolism III
PathBank:SMP0000958 Starch and Sucrose Metabolism
PathBank:SMP0000967 Colanic Acid Building Blocks Biosynthesis
Reactome:R-DME-71387 Carbohydrate metabolism
Reactome:R-DME-70370 Galactose catabolism
Reactome:R-MMU-1430728 Metabolism
Reactome:R-CEL-71387 Carbohydrate metabolism
Reactome:R-CEL-70370 Galactose catabolism
Reactome:R-DME-1430728 Metabolism
Reactome:R-HSA-71387 Carbohydrate metabolism
Reactome:R-HSA-70370 Galactose catabolism
Reactome:R-MMU-71387 Carbohydrate metabolism
Reactome:R-MMU-70370 Galactose catabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-CEL-1430728 Metabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-RNO-71387 Carbohydrate metabolism
Reactome:R-RNO-70370 Galactose catabolism
PathBank:SMP0000444 Lactose Synthesis
PathBank:SMP0000496 Galactosemia III
PathBank:SMP0000580 GLUT-1 Deficiency Syndrome
PathBank:SMP0002319 Leloir Pathway
PathBank:SMP0002331 Amino Sugar and Nucleotide Sugar Metabolism
PathBank:SMP0000043 Galactose Metabolism
PathBank:SMP0000182 Galactosemia
PathBank:SMP0000495 Galactosemia II (GALK)
PathBank:SMP0000579 Congenital Disorder of Glycosylation CDG-IId
PathBank:SMP0000010 Nucleotide Sugars Metabolism
PathBank:SMP0087448 Lactose Synthesis
PathBank:SMP0087439 Nucleotide Sugars Metabolism