EC: 2.5.1.6

methionine adenosyltransferase (ATP:L-methionine S-adenosyltransferase)

enzyme lambda metabolic reaction experiment
uniprot:P54419 [K+]

H2O + L_Methionine + ATP -> Phosphate + S_Adenosyl_L_methionine + Diphosphate		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-Cl
PH: 8
Temperature: 37
uniprot:P54419 [K+]

L_Methionine + ATP + H2O -> S_Adenosyl_L_methionine + Diphosphate + Phosphate		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-Cl
PH: 8
Temperature: 37
- [methionine adenosyltransferase(Enzyme) wildtype]

ATP + L_Methionine + H2O -> Phosphate + Diphosphate + S_Adenosyl_L_methionine		 (( (cytosol * Vmmat) ) / (1 + (( (Kmmat / Met) ) * (1 + (SAM / Kimetmat))))) buffer: *
PH: 7
Temperature: 36
uniprot:Q5U2R0 [Dimethyl sulfoxide]

ATP + L_Methionine + H2O -> Diphosphate + Phosphate + S_Adenosyl_L_methionine		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
uniprot:Q5U2R0 [Dimethyl sulfoxide]

ATP + H2O + L_Methionine -> Phosphate + S_Adenosyl_L_methionine + Diphosphate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
uniprot:Q5U2R0 [K+]

H2O + L_Methionine + ATP -> Diphosphate + Phosphate + S_Adenosyl_L_methionine		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
uniprot:Q5U2R0 [K+]

ATP + L_Methionine + H2O -> Diphosphate + S_Adenosyl_L_methionine + Phosphate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
uniprot:P18298 [K+]

H2O + L_Methionine + ATP -> Diphosphate + Phosphate + S_Adenosyl_L_methionine		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
uniprot:P18298 [K+]

L_Methionine + H2O + ATP -> Diphosphate + S_Adenosyl_L_methionine + Phosphate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
- [K+]

L_Methionine + H2O + ATP -> Diphosphate + Phosphate + S_Adenosyl_L_methionine		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
- [K+]

L_Methionine + ATP + H2O -> Diphosphate + Phosphate + S_Adenosyl_L_methionine		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
uniprot:Q5U2R0 [Dimethyl sulfoxide]

L_Methionine + H2O + ATP -> Diphosphate + Phosphate + S_Adenosyl_L_methionine		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
uniprot:Q5U2R0 [Dimethyl sulfoxide]

L_Methionine + H2O + ATP -> Diphosphate + Phosphate + S_Adenosyl_L_methionine		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
uniprot:P18298 [K+]

H2O + L_Methionine + ATP -> S_Adenosyl_L_methionine + Diphosphate + Phosphate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
uniprot:Q5U2R0 [K+]

L_Methionine + H2O + ATP -> Phosphate + Diphosphate + S_Adenosyl_L_methionine		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
uniprot:Q5U2R0 [K+]

ATP + L_Methionine + H2O -> Phosphate + S_Adenosyl_L_methionine + Diphosphate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
uniprot:P18298 [K+]

H2O + ATP + L_Methionine -> S_Adenosyl_L_methionine + Phosphate + Diphosphate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
- [K+]

ATP + L_Methionine + H2O -> S_Adenosyl_L_methionine + Diphosphate + Phosphate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37
- [K+]

L_Methionine + ATP + H2O -> S_Adenosyl_L_methionine + Diphosphate + Phosphate		 (( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.1 M Tris-HCl, 5 mM DTT
PH: 9
Temperature: 37

Pathways

pathway id name
BioCyc:HUMAN_PWY-6292 cysteine biosynthesis
BioCyc:HUMAN_PWY-5328 superpathway of methionine degradation
BioCyc:META_PWY-7527 L-methionine salvage cycle III
BioCyc:META_PWY0-781 aspartate superpathway
BioCyc:META_PWY-5328 superpathway of L-methionine salvage and degradation
BioCyc:META_ETHYL-PWY ethylene biosynthesis I (plants)
BioCyc:META_PWY-5041 S-adenosyl-L-methionine cycle II
BioCyc:META_PWY-6151 S-adenosyl-L-methionine cycle I
BioCyc:YEAST_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:YEAST_PWY-5041 S-adenosyl-L-methionine cycle II
BioCyc:YEAST_METHIONINE-DEG1-PWY methionine degradation I (to homocysteine)
BioCyc:ARA_METHIONINE-DEG1-PWY L-methionine degradation I (to L-homocysteine)
BioCyc:ARA_PWY-5041 S-adenosyl-L-methionine cycle II
BioCyc:VCHO_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:MTBH37RV_PWY-5041 S-adenosyl-L-methionine cycle II
BioCyc:ECOL316407_PWY0-781 aspartate superpathway
BioCyc:PDIF272563_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:BTHE_METHIONINE-DEG1-PWY methionine degradation I (to homocysteine)
BioCyc:CORYNE_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:CORYNE_PWY0-781 aspartate superpathway
BioCyc:CORYNE_MET-SAM-PWY superpathway of S-adenosyl-L-methionine biosynthesis
BioCyc:CORYNE_PWY-5041 S-adenosyl-L-methionine cycle II
BioCyc:GCF_000013425_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:HUMAN_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:META_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:META_PWY-7528 L-methionine salvage cycle I (bacteria and plants)
BioCyc:META_PWY-7270 L-methionine salvage cycle II (plants)
BioCyc:ARA_PWY-7528 L-methionine salvage cycle I (bacteria and plants)
BioCyc:ECOO157_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:ECOO157_PWY-6151 S-adenosyl-L-methionine cycle I
BioCyc:ECOO157_MET-SAM-PWY superpathway of S-adenosyl-L-methionine biosynthesis
BioCyc:ANTHRA_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:MOUSE_PWY-5328 superpathway of methionine degradation
BioCyc:MOUSE_PWY-6292 cysteine biosynthesis III (mammalia)
BioCyc:MOUSE_METHIONINE-DEG1-PWY methionine degradation I (to homocysteine)
BioCyc:BSUB_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:SYNEL_PWY-6292 superpathway of L-cysteine biosynthesis (mammalian)
BioCyc:ECOL316407_PWY-6151 S-adenosyl-L-methionine cycle I
BioCyc:ECOL316407_MET-SAM-PWY superpathway of S-adenosyl-L-methionine biosynthesis
BioCyc:BTHE_PWY-6151 S-adenosyl-L-methionine cycle I
BioCyc:BTHE_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:GCF_000013425_PWY-6151 S-adenosyl-L-methionine cycle I
BioCyc:HUMAN_PWY-7527 methionine salvage cycle III
BioCyc:META_PWY-5912 2'-deoxymugineic acid phytosiderophore biosynthesis
BioCyc:META_PWY-I9 L-cysteine biosynthesis VI (from L-methionine)
BioCyc:META_PWY-6292 superpathway of L-cysteine biosynthesis (mammalian)
BioCyc:META_METHIONINE-DEG1-PWY L-methionine degradation I (to L-homocysteine)
BioCyc:ECO_MET-SAM-PWY superpathway of S-adenosyl-L-methionine biosynthesis
BioCyc:ECO_PWY-6151 S-adenosyl-L-methionine cycle I
BioCyc:ARA_ETHYL-PWY ethylene biosynthesis I (plants)
BioCyc:VCHO_PWY0-781 aspartate superpathway
BioCyc:MTBH37RV_PWY-I9 L-cysteine biosynthesis VI (from L-methionine)
BioCyc:MTBH37RV_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:MTBH37RV_METHIONINE-DEG1-PWY L-methionine degradation I (to L-homocysteine)
BioCyc:HPY_PWY-I9 L-cysteine biosynthesis VI (from L-methionine)
BioCyc:ANTHRA_PWY0-781 aspartate superpathway
BioCyc:MOUSE_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:MOUSE_PWY-5041 S-adenosyl-L-methionine cycle II
BioCyc:BSUB_PWY-6151 S-adenosyl-L-methionine cycle I
BioCyc:SYNEL_METHIONINE-DEG1-PWY L-methionine degradation I (to L-homocysteine)
BioCyc:SYNEL_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:PDIF272563_MET-SAM-PWY superpathway of S-adenosyl-L-methionine biosynthesis
BioCyc:CORYNE_PWY-6151 S-adenosyl-L-methionine cycle I
BioCyc:CORYNE_METHIONINE-DEG1-PWY L-methionine degradation I (to L-homocysteine)
BioCyc:HUMAN_METHIONINE-DEG1-PWY methionine degradation
BioCyc:META_MET-SAM-PWY superpathway of S-adenosyl-L-methionine biosynthesis
BioCyc:ECO_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:ECO_PWY0-781 aspartate superpathway
BioCyc:ARA_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:ARA_PWY-7270 L-methionine salvage cycle II (plants)
BioCyc:VCHO_PWY-6151 S-adenosyl-L-methionine cycle I
BioCyc:VCHO_PWY-I9 L-cysteine biosynthesis VI (from L-methionine)
BioCyc:HPY_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:ECOO157_PWY0-781 aspartate superpathway
BioCyc:ANTHRA_PWY-6151 S-adenosyl-L-methionine cycle I
BioCyc:ANTHRA_MET-SAM-PWY superpathway of S-adenosyl-L-methionine biosynthesis
BioCyc:BSUB_MET-SAM-PWY superpathway of S-adenosyl-L-methionine biosynthesis
BioCyc:SYNEL_MET-SAM-PWY superpathway of S-adenosyl-L-methionine biosynthesis
BioCyc:ECOL316407_SAM-PWY S-adenosyl-L-methionine biosynthesis
BioCyc:PDIF272563_PWY-6151 S-adenosyl-L-methionine cycle I
PathBank:SMP0000857 S-Adenosyl-L-Methionine Biosynthesis
PathBank:SMP0002092 S-Adenosyl-L-Methionine Cycle
PlantCyc:ARA_SAM-PWY S-adenosyl-L-methionine biosynthesis
PlantCyc:ARA_PWY-7270 L-methionine salvage cycle II (plants)
PlantCyc:ORYZA_PWY-7270 L-methionine salvage cycle II (plants)
PlantCyc:PLANT_SAM-PWY S-adenosyl-L-methionine biosynthesis
PlantCyc:PLANT_PWY-7270 L-methionine salvage cycle II (plants)
PlantCyc:PLANT_PWY-5041 S-adenosyl-L-methionine cycle II
PlantCyc:PLANT_ETHYL-PWY ethylene biosynthesis I (plants)
PlantCyc:ARA_METHIONINE-DEG1-PWY L-methionine degradation I (to L-homocysteine)
PlantCyc:ARA_ETHYL-PWY ethylene biosynthesis I (plants)
PlantCyc:ARA_PWY-5041 S-adenosyl-L-methionine cycle II
PlantCyc:ORYZA_PWY-7528 L-methionine salvage cycle I (bacteria and plants)
PlantCyc:ORYZA_METHIONINE-DEG1-PWY L-methionine degradation I (to L-homocysteine)
PlantCyc:ORYZA_PWY-5041 S-adenosyl-L-methionine cycle II
PlantCyc:PLANT_PWY-5912 2'-deoxymugineic acid phytosiderophore biosynthesis
PlantCyc:ARA_PWY-7528 L-methionine salvage cycle I (bacteria and plants)
PlantCyc:ORYZA_SAM-PWY S-adenosyl-L-methionine biosynthesis
PlantCyc:ORYZA_ETHYL-PWY ethylene biosynthesis I (plants)
PlantCyc:ORYZA_PWY-5912 2'-deoxymugineic acid phytosiderophore biosynthesis
PlantCyc:PLANT_METHIONINE-DEG1-PWY L-methionine degradation I (to L-homocysteine)
Reactome:R-DDI-211859 Biological oxidations
Reactome:R-HSA-211859 Biological oxidations
Reactome:R-HSA-156581 Methylation
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-211859 Biological oxidations
Reactome:R-MMU-156581 Methylation
Reactome:R-HSA-156580 Phase II - Conjugation of compounds
Reactome:R-MMU-156580 Phase II - Conjugation of compounds
Reactome:R-RNO-211859 Biological oxidations
Reactome:R-RNO-156581 Methylation
Reactome:R-DDI-156580 Phase II - Conjugation of compounds
Reactome:R-DDI-156581 Methylation
Reactome:R-RNO-1430728 Metabolism
Reactome:R-DDI-1430728 Metabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-RNO-156580 Phase II - Conjugation of compounds
WikiPathways:WP4224 Purine metabolism and related disorders
WikiPathways:WP4292 Methionine metabolism leading to sulfur amino acids and related disorders
PathBank:SMP0120718 Hypermethioninemia
PathBank:SMP0108776 Sarcosine Oncometabolite Pathway
PathBank:SMP0000177 Cystathionine beta-Synthase Deficiency
PathBank:SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0002313 Sarcosine Oncometabolite Pathway
PathBank:SMP0087161 Selenoamino Acid Metabolism
PathBank:SMP0087213 Spermidine and Spermine Biosynthesis
PathBank:SMP0087342 Methionine Metabolism
PathBank:SMP0087442 Spermidine and Spermine Biosynthesis
PathBank:SMP0063600 Betaine Metabolism
PathBank:SMP0120853 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
PathBank:SMP0120471 Cystathionine beta-Synthase Deficiency
PathBank:SMP0120487 Glycine N-Methyltransferase Deficiency
PathBank:SMP0120519 Methionine Adenosyltransferase Deficiency
PathBank:SMP0120527 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0000033 Methionine Metabolism
PathBank:SMP0000222 Glycine N-Methyltransferase Deficiency
PathBank:SMP0002307 beta-Alanine Metabolism
PathBank:SMP0087249 Methionine Metabolism
PathBank:SMP0087273 Selenoamino Acid Metabolism
PathBank:SMP0087285 Betaine Metabolism
PathBank:SMP0063587 Selenoamino Acid Metabolism
PathBank:SMP0063637 Methionine Metabolism
PathBank:SMP0108762 Sarcosine Oncometabolite Pathway
PathBank:SMP0120634 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
PathBank:SMP0121301 S-Adenosyl-L-Methionine Biosynthesis
PathBank:SMP0000123 Betaine Metabolism
PathBank:SMP0000341 Hypermethioninemia
PathBank:SMP0000221 Methionine Adenosyltransferase Deficiency
PathBank:SMP0002439 Methionine Metabolism
PathBank:SMP0087308 Spermidine and Spermine Biosynthesis
PathBank:SMP0063671 Spermidine and Spermine Biosynthesis
PathBank:SMP0120691 Cystathionine beta-Synthase Deficiency
PathBank:SMP0120707 Glycine N-Methyltransferase Deficiency
PathBank:SMP0120739 Methionine Adenosyltransferase Deficiency
PathBank:SMP0120747 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0120498 Hypermethioninemia
PathBank:SMP0000029 Selenoamino Acid Metabolism
PathBank:SMP0000445 Spermidine and Spermine Biosynthesis
PathBank:SMP0000214 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
PathBank:SMP0002310 Methionine Metabolism and Salvage
PathBank:SMP0087182 Betaine Metabolism
PathBank:SMP0087423 Selenoamino Acid Metabolism
PathBank:SMP0087483 Methionine Metabolism