EC: 1.1.1.42

isocitrate dehydrogenase (NADP+) (isocitrate:NADP+ oxidoreductase (decarboxylating))

enzyme lambda metabolic reaction experiment
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> CO2 + NADPH + H+ + 2_Oxoglutarate
(( (Vmax * M) ) / (Km + M)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + H+ + CO2 + NADPH
(( (Vmax * M) ) / (Km + M)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> H+ + CO2 + 2_Oxoglutarate + NADPH
(( (Vmax * M) ) / (Km + M)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> NADPH + CO2 + H+ + 2_Oxoglutarate
(( (Vmax * M) ) / (Km + M)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> NADPH + 2_Oxoglutarate + CO2 + H+
(( (Vmax * A) ) / (Ka + A)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + CO2 + H+ + NADPH
(( (Vmax * M) ) / (Km + M)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> NADPH + CO2 + 2_Oxoglutarate + H+
(( (Vmax * A) ) / (Ka + A)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> CO2 + NADPH + 2_Oxoglutarate + H+
(( (Vmax * B) ) / (Kb + B)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> CO2 + H+ + NADPH + 2_Oxoglutarate
(( (Vmax * B) ) / (Kb + B)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> NADPH + H+ + CO2 + 2_Oxoglutarate
(( (Vmax * B) ) / (Kb + B)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> CO2 + NADPH + 2_Oxoglutarate + H+
(( (Vmax * B) ) / (Kb + B)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> H+ + NADPH + 2_Oxoglutarate + CO2
(( (Vmax * B) ) / (Kb + B)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> 2_Oxoglutarate + NADPH + H+ + CO2
(( (Vmax * A) ) / (Ka + A)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + H+ + CO2 + NADPH
(( (Vmax * A) ) / (Ka + A)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> NADPH + CO2 + H+ + 2_Oxoglutarate
(( (Vmax * A) ) / (Ka + A)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
- [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype isozyme 1]

Isocitrate + NADP+ -> CO2 + H+ + NADPH + 2_Oxoglutarate
(( (Vmax * A) ) / (Km_A + A)) buffer: 0.05 M Tris, 1 mM MnCl2
PH: 7.4
Temperature: 23
- [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype isozyme 1]

NADP+ + Isocitrate -> 2_Oxoglutarate + H+ + CO2 + NADPH
(( (Vmax * B) ) / (Km_B + B)) buffer: 0.05 M Tris, 1 mM MnCl2
PH: 7.4
Temperature: 23
- [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype isozyme 2]

Isocitrate + NADP+ -> H+ + 2_Oxoglutarate + NADPH + CO2
(( (Vmax * B) ) / (Km_B + B)) buffer: 0.05 M Tris, 1 mM MnCl2
PH: 7.4
Temperature: 23
- [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype isozyme 2]

NADP+ + Isocitrate -> 2_Oxoglutarate + NADPH + H+ + CO2
(( (Vmax * A) ) / (Km_A + A)) buffer: 0.05 M Tris, 1 mM MnCl2
PH: 7.4
Temperature: 23
- [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype isozyme 2]

NADP+ + Oxalosuccinate -> CO2 + H+ + 2_Oxoglutarate + NADPH
(( (Vmax * A) ) / (Km_A + A)) buffer: 0.05 M Tris, 1 mM MnCl2
PH: 7.4
Temperature: 23
uniprot:P9WKL1 [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype ICDH-1, N-terminal His-tag]

Isocitrate + NADP+ -> CO2 + H+ + NADPH + 2_Oxoglutarate
(( (( (( (E * kcat) ) * A) ) * B) ) / (( (( (( (Kia * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 100 mM HEPES, 5 mM MnCl2
PH: 7.5
Temperature: 22
uniprot:P9WKL1 [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype ICDH-1, N-terminal His-tag]

NADPH + H+ + 2_Oxoglutarate -> 2_Hydroxyglutarate + NADP+
(( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM HEPES, 150 mM NaCl
PH: 7.5
Temperature: 23
uniprot:P08200 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant K344D, Y345I, V351A, Y391K, R395S, Q316L, V317P, G319S, I320L]

NADP+ + Isocitrate -> 2_Oxoglutarate + H+ + CO2 + NADPH
(( (Vmax * A) ) / (Km + A)) buffer: 25 mM Mops, 100 mM NaCl, 5 mM MgCl2, 1 mM DTT
PH: 7.5
Temperature: 21
uniprot:Q8G490 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + H+ + NADPH + CO2
(( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 35 mM Tris-HCl
PH: 8
Temperature: 25
uniprot:Q8G490 [Mg2+]

Isocitrate + NADP+ -> NADPH + 2_Oxoglutarate + H+ + CO2
(( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 35 mM Tris-HCl
PH: 8
Temperature: 25
uniprot:O75874 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant IDH1 R132H, C-terminal His-tag]

H+ + NADPH + 2_Oxoglutarate -> NADP+ + (R)_2_Hydroxyglutarate
(( (Vmax * A) ) / (Km + A)) buffer: 50 mM HEPES, 0.1 mg/ml BSA, 4 mM MgCl2
PH: 7.5
Temperature: 36
uniprot:O75874 [Mn2+]

NADP+ + Isocitrate -> CO2 + 2_Oxoglutarate + H+ + NADPH
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M triethanolamine
PH: 7.3
Temperature: 37
uniprot:O75874 [Mn2+]

Isocitrate + NADP+ -> NADPH + H+ + 2_Oxoglutarate + CO2
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M triethanolamine
PH: 7.3
Temperature: 37
uniprot:O75874 [Mn2+]

Isocitrate + NADP+ -> H+ + 2_Oxoglutarate + NADPH + CO2
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M triethanolamine
PH: 7.3
Temperature: 37
uniprot:O75874 [Mn2+]

NADP+ + Isocitrate -> CO2 + H+ + 2_Oxoglutarate + NADPH
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M triethanolamine
PH: 7.3
Temperature: 37
uniprot:O75874 [Mn2+]

NADP+ + Isocitrate -> CO2 + 2_Oxoglutarate + NADPH + H+
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M triethanolamine
PH: 7.3
Temperature: 37
uniprot:O75874 [Mn2+]

Isocitrate + NADP+ -> H+ + NADPH + 2_Oxoglutarate + CO2
(( (Vmax * B) ) / (Km + B)) buffer: 0.1 M triethanolamine
PH: 7.3
Temperature: 37
uniprot:O75874 [Mn2+]

NADP+ + Isocitrate -> CO2 + 2_Oxoglutarate + NADPH + H+
(( (Vmax * B) ) / (Km + B)) buffer: 0.1 M triethanolamine
PH: 7.3
Temperature: 37
uniprot:O75874 [Nicotinic acid adenine dinucleotide phosphate]

2_Oxoglutarate + CO2 + NADPH + H+ -> Isocitrate + NADP+
(( (Vmax * C) ) / (( (Km * (1 + (I / Kis))) ) + (C * (1 + (I / Kii))))) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 25
uniprot:O75874 [Nicotinic acid adenine dinucleotide phosphate]

2_Oxoglutarate + NADPH + H+ + CO2 -> Isocitrate + NADP+
(( (Vmax * A) ) / (( (Km + A) ) * (1 + (I / Ki)))) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 25
uniprot:O75874 [Nicotinic acid adenine dinucleotide phosphate]

2_Oxoglutarate + CO2 + H+ + NADPH -> Isocitrate + NADP+
(( (Vmax * B) ) / (( (Km * (1 + (I / Ki))) ) + B)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 25
uniprot:O75874 [Nicotinic acid adenine dinucleotide phosphate]

H+ + 2_Oxoglutarate + NADPH -> NADP+ + (R)_2_Hydroxyglutarate
(( (Vmax * A) ) / (( (Km + A) ) * (1 + (I / Ki)))) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 22
uniprot:O75874 [Nicotinic acid adenine dinucleotide phosphate]

NADPH + H+ + 2_Oxoglutarate -> NADP+ + (R)_2_Hydroxyglutarate
(( (Vmax * B) ) / (( (Km * (1 + (I / Ki))) ) + B)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 22
uniprot:O75874 [N-Oxaloglycine]

NADPH + H+ + 2_Oxoglutarate -> NADP+ + (R)_2_Hydroxyglutarate
(( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 22
uniprot:O75874 [N-Oxaloglycine]

NADPH + H+ + 2_Oxoglutarate -> NADP+ + (R)_2_Hydroxyglutarate
(( (Vmax * B) ) / (Km + (B * (1 + (I / Ki))))) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 22
uniprot:O75874 [N-Oxaloglycine]

H+ + NADPH + 2_Oxoglutarate -> NADP+ + (R)_2_Hydroxyglutarate
(( (Vmax * B) ) / (Km + (B * (1 + (I / Ki))))) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 22
uniprot:O75874 [N-Oxaloglycine]

2_Oxoglutarate + H+ + NADPH -> NADP+ + (R)_2_Hydroxyglutarate
(( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 22
uniprot:P08200 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant K344D, Y345I, V351A, Y391K, R395S, C332Y]

NADP+ + Isocitrate -> 2_Oxoglutarate + H+ + NADPH + CO2
(( (Vmax * A) ) / (Km + A)) buffer: 25 mM Mops, 100 mM NaCl, 5 mM MgCl2, 1 mM DTT
PH: 7.5
Temperature: 21
uniprot:P08200 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant K344D, Y345I, V351A, Y391K, R395S]

NADP+ + Isocitrate -> CO2 + H+ + NADPH + 2_Oxoglutarate
(( (Vmax * A) ) / (Km + A)) buffer: 25 mM Mops, 100 mM NaCl, 5 mM MgCl2, 1 mM DTT
PH: 7.5
Temperature: 21
uniprot:P08200 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant K344D, Y345I, V351A, Y391K, R395S, R292D]

NADP+ + Isocitrate -> H+ + 2_Oxoglutarate + NADPH + CO2
(( (Vmax * A) ) / (Km + A)) buffer: 25 mM Mops, 100 mM NaCl, 5 mM MgCl2, 1 mM DTT
PH: 7.5
Temperature: 21
uniprot:P08200 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant K344D, Y345I, V351A, Y391K, R395S, C332Y, C201I]

Isocitrate + NADP+ -> NADPH + H+ + 2_Oxoglutarate + CO2
(( (Vmax * A) ) / (Km + A)) buffer: 25 mM Mops, 100 mM NaCl, 5 mM MgCl2, 1 mM DTT
PH: 7.5
Temperature: 21
uniprot:Q8G490 [Mg2+]

Isocitrate + NADP+ -> CO2 + H+ + 2_Oxoglutarate + NADPH
(( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 35 mM Tris-HCl
PH: 8
Temperature: 25
uniprot:O75874 [N-Oxaloglycine]

CO2 + NADPH + 2_Oxoglutarate + H+ -> NADP+ + Isocitrate
(( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 25
uniprot:O75874 [N-Oxaloglycine]

NADPH + CO2 + 2_Oxoglutarate + H+ -> NADP+ + Isocitrate
(( (Vmax * B) ) / (( (Km + B) ) * (1 + (I / Ki)))) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 25
uniprot:O75874 [N-Oxaloglycine]

CO2 + NADPH + 2_Oxoglutarate + H+ -> Isocitrate + NADP+
(( (Vmax * C) ) / (( (Km + C) ) * (1 + (I / Ki)))) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 25
uniprot:O75874 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant IDH1 (G97D) His-tagged]

NADP+ + Isocitrate -> 2_Oxoglutarate + NADPH + H+ + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 12.5 µM resazurin, 1.25 U/ml diaphorase
PH: 8
Temperature: 36
uniprot:O75874 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant IDH1 (Y139D) His-tagged]

NADP+ + Isocitrate -> CO2 + H+ + 2_Oxoglutarate + NADPH
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 12.5 µM resazurin, 1.25 U/ml diaphorase
PH: 8
Temperature: 36
uniprot:O75874 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant IDH1 (G97N) His-tagged]

Isocitrate + NADP+ -> CO2 + 2_Oxoglutarate + NADPH + H+
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 12.5 µM resazurin, 1.25 U/ml diaphorase
PH: 8
Temperature: 36
- [Mn2+]

NADP+ + Isocitrate -> H+ + CO2 + NADPH + 2_Oxoglutarate
(( (Vmax * B) ) / (Km + B)) buffer: 30 mM Triethanolamine chloride
PH: 7.4
Temperature: 20
- [Mn2+]

Isocitrate + NADP+ -> H+ + CO2 + NADPH + 2_Oxoglutarate
(( (Vmax * A) ) / (Km + A)) buffer: 30 mM Triethanolamine chloride
PH: 7.4
Temperature: 20
uniprot:P9WKL1 [Malate]

NADP+ + Isocitrate -> 2_Oxoglutarate + H+ + NADPH + CO2
(( (Vmax * S) ) / (( (Km * (1 + (I / Kis))) ) + (S * (1 + (I / Kii))))) buffer: 100 mM HEPES, 5 mM MnCl2
PH: 7.5
Temperature: 22
uniprot:P9WKL1 [Malate]

NADP+ + Isocitrate -> CO2 + H+ + 2_Oxoglutarate + NADPH
(( (Vmax * S) ) / (( (Km * (1 + (I / Kis))) ) + (S * (1 + (I / Kii))))) buffer: 100 mM HEPES, 5 mM MnCl2
PH: 7.5
Temperature: 22
uniprot:P9WKL1 [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype ICDH-1, N-terminal His-tag]

Isocitrate + NADP+ -> CO2 + NADPH + H+ + 2_Oxoglutarate
(( (Vmax * S) ) / (( (Km * (1 + (I / Kis))) ) + (S * (1 + (I / Kii))))) buffer: 100 mM HEPES, 5 mM MnCl2
PH: 7.5
Temperature: 22
uniprot:P9WKL1 [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype ICDH-1, N-terminal His-tag]

Isocitrate + NADP+ -> NADPH + CO2 + H+ + 2_Oxoglutarate
(( (Vmax * S) ) / (( (Km * (1 + (I / Kis))) ) + (S * (1 + (I / Kii))))) buffer: 100 mM HEPES, 5 mM MnCl2
PH: 7.5
Temperature: 22
uniprot:P08200 [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype]

Isocitrate + NADP+ -> CO2 + 2_Oxoglutarate + H+ + NADPH
(( (Vmax * A) ) / (Km + A)) buffer: 25 mM Mops, 100 mM NaCl, 5 mM MgCl2, 1 mM DTT
PH: 7.5
Temperature: 21
uniprot:P9WKL1 [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype ICDH-1, N-terminal His-tag]

Isocitrate + NADP+ -> NADPH + CO2 + H+ + 2_Oxoglutarate
(( (Vmax * S) ) / (( (Km * (1 + (I / Kis))) ) + S)) buffer: 100 mM HEPES, 5 mM MnCl2
PH: 7.5
Temperature: 22
uniprot:P08200 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant K344D, Y345I]

NADP+ + Isocitrate -> H+ + NADPH + CO2 + 2_Oxoglutarate
(( (Vmax * A) ) / (Km + A)) buffer: 25 mM Mops, 100 mM NaCl, 5 mM MgCl2, 1 mM DTT
PH: 7.5
Temperature: 21
uniprot:P08200 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant K344D, Y345I, V351A]

NADP+ + Isocitrate -> H+ + CO2 + NADPH + 2_Oxoglutarate
(( (Vmax * A) ) / (Km + A)) buffer: 25 mM Mops, 100 mM NaCl, 5 mM MgCl2, 1 mM DTT
PH: 7.5
Temperature: 21
uniprot:P9WKL1 [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype ICDH-1, N-terminal His-tag]

2_Oxoglutarate + NADPH + H+ -> NADP+ + 2_Hydroxyglutarate
(( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM HEPES, 150 mM NaCl
PH: 7.5
Temperature: 22
uniprot:O75874 [GSK849]

NADPH + H+ + 2_Oxoglutarate -> NADP+ + 2_Hydroxyglutarate
(( (Vmax * B) ) / (( (Km * (1 + (I / Kis))) ) + (B * (1 + (I / Kii))))) buffer: 100 mM Tris, 10 mM MgCl2, 1 mM CHAPS, 0.1 mg/ml BSA, 0.2 mM DTT
PH: 8
Temperature: 22
uniprot:O75874 [GSK849]

NADPH + 2_Oxoglutarate + H+ -> NADP+ + 2_Hydroxyglutarate
(( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 100 mM Tris, 10 mM MgCl2, 1 mM CHAPS, 0.1 mg/ml BSA, 0.2 mM DTT
PH: 8
Temperature: 22
uniprot:O75874 [Mn2+]

NADP+ + Isocitrate -> CO2 + H+ + 2_Oxoglutarate + NADPH
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M triethanolamine
PH: 7.3
Temperature: 37
uniprot:O75874 [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype IDH1, His-tagged]

NADP+ + Isocitrate -> 2_Oxoglutarate + NADPH + H+ + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 12.5 µM resazurin, 1.25 U/ml diaphorase
PH: 8
Temperature: 36
uniprot:O75874 [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype IDH1, His-tagged]

NADP+ + Isocitrate -> CO2 + H+ + NADPH + 2_Oxoglutarate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 12.5 µM resazurin, 1.25 U/ml diaphorase
PH: 8
Temperature: 36
uniprot:O75874 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant IDH1 (R132H) His-tagged]

Isocitrate + NADP+ -> CO2 + H+ + 2_Oxoglutarate + NADPH
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 12.5 µM resazurin, 1.25 U/ml diaphorase
PH: 8
Temperature: 36
uniprot:O75874 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant IDH1 (G97D) His-tagged]

Isocitrate + NADP+ -> CO2 + NADPH + H+ + 2_Oxoglutarate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 12.5 µM resazurin, 1.25 U/ml diaphorase
PH: 8
Temperature: 36
uniprot:O75874 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant IDH1 (Y139D) His-tagged]

Isocitrate + NADP+ -> 2_Oxoglutarate + CO2 + NADPH + H+
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 12.5 µM resazurin, 1.25 U/ml diaphorase
PH: 8
Temperature: 36
uniprot:O75874 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant IDH1 (G97N) His-tagged]

Isocitrate + NADP+ -> H+ + NADPH + 2_Oxoglutarate + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 12.5 µM resazurin, 1.25 U/ml diaphorase
PH: 8
Temperature: 36
uniprot:O75874 [isocitrate dehydrogenase (NADP+)(Enzyme) mutant IDH1 (R132H) His-tagged]

Isocitrate + NADP+ -> CO2 + H+ + NADPH + 2_Oxoglutarate
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 12.5 µM resazurin, 1.25 U/ml diaphorase
PH: 8
Temperature: 36
uniprot:O75874 [N-Oxaloglycine]

NADPH + H+ + 2_Oxoglutarate -> (R)_2_Hydroxyglutarate + NADP+
(( (Vmax * B) ) / (Km + (B * (1 + (I / Ki))))) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 22
uniprot:O75874 [N-Oxaloglycine]

NADPH + 2_Oxoglutarate + H+ -> NADP+ + (R)_2_Hydroxyglutarate
(( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 22
uniprot:O75874 [N-Oxaloglycine]

H+ + 2_Oxoglutarate + NADPH -> NADP+ + (R)_2_Hydroxyglutarate
(( (Vmax * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 22
uniprot:O75874 [N-Oxaloglycine]

NADPH + H+ + 2_Oxoglutarate -> NADP+ + (R)_2_Hydroxyglutarate
(( (Vmax * B) ) / (Km + (B * (1 + (I / Ki))))) buffer: 100 mM Tris, 10 mM MgCl2, 0.05% CHAPS, 0.01% BSA, 0.1 mM DTT
PH: 8
Temperature: 22
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> H+ + 2_Oxoglutarate + NADPH + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> H+ + 2_Oxoglutarate + NADPH + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + H+ + NADPH + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> H+ + NADPH + 2_Oxoglutarate + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> NADPH + 2_Oxoglutarate + CO2 + H+
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> NADPH + CO2 + 2_Oxoglutarate + H+
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> H+ + 2_Oxoglutarate + CO2 + NADPH
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> H+ + CO2 + 2_Oxoglutarate + NADPH
(( (Vmax * S) ) / (Km + S)) buffer: 0.2 M sodium acetate
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + H+ + NADPH + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P08200 [Mg2+]

NADP+ + Isocitrate -> 2_Oxoglutarate + NADPH + CO2 + H+
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NADP+ -> H+ + NADPH + 2_Oxoglutarate + CO2
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NADP+ -> H+ + 2_Oxoglutarate + NADPH + CO2
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NAD+ -> NADH + CO2 + H+ + 2_Oxoglutarate
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NAD+ + Isocitrate -> H+ + 2_Oxoglutarate + NADH + CO2
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NADP+ + L_Malate -> NADPH + Pyruvate + CO2 + H+
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NADP+ + L_Malate -> Pyruvate + H+ + CO2 + NADPH
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Adenosine 2',5'-bisphosphate]

H+ + NADPH + CO2 + 2_Oxoglutarate -> NADP+ + Isocitrate
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Adenosine 2',5'-bisphosphate]

Isocitrate + NADP+ -> H+ + 2_Oxoglutarate + CO2 + NADPH
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Adenosine 2',5'-bisphosphate]

CO2 + 2_Oxoglutarate + H+ + NADPH -> Isocitrate + NADP+
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + A)) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

H+ + 2_Oxoglutarate + CO2 + NADPH -> Isocitrate + NADP+
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NADPH + 2_Oxoglutarate + H+ + CO2 -> NADP+ + Isocitrate
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

2_Oxoglutarate + CO2 + NADPH + H+ -> NADP+ + Isocitrate
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

2_Oxoglutarate + NADPH + H+ + CO2 -> Isocitrate + NADP+
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

CO2 + H+ + NADPH + 2_Oxoglutarate -> Isocitrate + NADP+
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + A)) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NADPH + CO2 + 2_Oxoglutarate + H+ -> NADP+ + Isocitrate
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + A)) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Adenosine 2',5'-bisphosphate]

NADP+ + Isocitrate -> NADPH + CO2 + H+ + 2_Oxoglutarate
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Adenosine 2',5'-bisphosphate]

Isocitrate + NADP+ -> CO2 + H+ + 2_Oxoglutarate + NADPH
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + A)) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NADP+ -> NADPH + 2_Oxoglutarate + CO2 + H+
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NADP+ + Isocitrate -> CO2 + NADPH + 2_Oxoglutarate + H+
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + A)) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NADP+ -> H+ + 2_Oxoglutarate + NADPH + CO2
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NADP+ + Isocitrate -> 2_Oxoglutarate + H+ + CO2 + NADPH
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NADP+ + Isocitrate -> CO2 + 2_Oxoglutarate + NADPH + H+
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NADP+ + Isocitrate -> CO2 + 2_Oxoglutarate + H+ + NADPH
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + A)) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NADP+ -> H+ + NADPH + CO2 + 2_Oxoglutarate
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + A)) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NAD+ -> CO2 + NADH + H+ + 2_Oxoglutarate
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

L_Malate + NADP+ -> NADPH + H+ + Pyruvate + CO2
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
- [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype]

NADP+ + Isocitrate -> 2_Oxoglutarate + CO2 + NADPH + H+
(( (Vmax * S) ) / (Km + S)) buffer: 25 mM KH2PO4-KOH, 10 mM MgCl2
PH: 7.5
Temperature: 30
- [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype]

Isocitrate + NADP+ -> H+ + NADPH + CO2 + 2_Oxoglutarate
(( (Vmax * S) ) / (Km + S)) buffer: 25 mM KH2PO4-KOH, 10 mM MgCl2
PH: 7.5
Temperature: 30
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> CO2 + 2_Oxoglutarate + H+ + NADPH
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> CO2 + H+ + NADPH + 2_Oxoglutarate
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> CO2 + NADPH + 2_Oxoglutarate + H+
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + NADPH + H+ + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> CO2 + 2_Oxoglutarate + H+ + NADPH
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + NADPH + H+ + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> NADPH + H+ + 2_Oxoglutarate + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> 2_Oxoglutarate + CO2 + H+ + NADPH
(( (Vmax * S) ) / (Km + S)) buffer: 0.2 M sodium acetate
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> CO2 + NADPH + H+ + 2_Oxoglutarate
(( (Vmax * S) ) / (Km + S)) buffer: 0.2 M sodium acetate
PH: 5
Temperature: 25
uniprot:P08200 [Adenosine 2',5'-bisphosphate]

Isocitrate + NADP+ -> NADPH + 2_Oxoglutarate + CO2 + H+
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NADP+ -> H+ + NADPH + CO2 + 2_Oxoglutarate
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NADP+ + Isocitrate -> CO2 + 2_Oxoglutarate + H+ + NADPH
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + A)) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NADP+ -> CO2 + 2_Oxoglutarate + NADPH + H+
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NADP+ -> CO2 + H+ + 2_Oxoglutarate + NADPH
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NADP+ -> H+ + 2_Oxoglutarate + CO2 + NADPH
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + NADPH + H+ + CO2
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NAD+ -> CO2 + NADH + H+ + 2_Oxoglutarate
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NADP+ + L_Malate -> NADPH + CO2 + Pyruvate + H+
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [2-Oxoglutarate]

NADP+ + L_Malate -> Pyruvate + CO2 + H+ + NADPH
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NAD+ + Isocitrate -> CO2 + NADH + H+ + 2_Oxoglutarate
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [2-Oxoglutarate]

NADP+ + L_Malate -> CO2 + H+ + NADPH + Pyruvate
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + A)) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NAD+ -> 2_Oxoglutarate + H+ + NADH + CO2
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + A)) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NAD+ + Isocitrate -> CO2 + H+ + 2_Oxoglutarate + NADH
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NADP+ + L_Malate -> CO2 + NADPH + H+ + Pyruvate
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + H+ + CO2 + NADPH
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + A)) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NAD+ -> NADH + 2_Oxoglutarate + CO2 + H+
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + A)) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

L_Malate + NADP+ -> NADPH + Pyruvate + CO2 + H+
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + A)) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + CO2 + NADPH + H+
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + (A * (1 + (I / K_ii))))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + NADPH + CO2 + H+
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NADP+ + Isocitrate -> 2_Oxoglutarate + NADPH + H+ + CO2
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NADP+ + Isocitrate -> NADPH + CO2 + 2_Oxoglutarate + H+
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

NADP+ + L_Malate -> H+ + CO2 + Pyruvate + NADPH
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NAD+ -> 2_Oxoglutarate + CO2 + NADH + H+
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

L_Malate + NADP+ -> NADPH + CO2 + H+ + Pyruvate
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NADP+ -> CO2 + 2_Oxoglutarate + H+ + NADPH
(( (( (kcat * E) ) * A) ) / (( (Km_A * (1 + (I / K_is))) ) + A)) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P08200 [Mg2+]

Isocitrate + NAD+ -> CO2 + NADH + H+ + 2_Oxoglutarate
(( (( (( (kcat * E) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 25 mM MOPS, 100 mM NaCl, 1 mM DTT
PH: 7.3
Temperature: 21
uniprot:P56574 [Mn2+]

NADP+ + D_Isocitrate -> CO2 + NADPH + 2_Oxoglutarate + H+
(( (Vmax * S) ) / (Km + S)) buffer: 0.1 M Tris-HCl
PH: 7.5
Temperature: 25
uniprot:P41562 [Mn2+]

NADP+ + D_Isocitrate -> CO2 + 2_Oxoglutarate + NADPH + H+
(( (Vmax * S) ) / (Km + S)) buffer: 0.1 M Tris-HCl
PH: 7.5
Temperature: 25
uniprot:P41562 [Mn2+]

D_Isocitrate + NADP+ -> NADPH + 2_Oxoglutarate + H+ + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 0.1 M Tris-HCl
PH: 7.5
Temperature: 25
uniprot:P56574 [Mn2+]

NADP+ + D_Isocitrate -> 2_Oxoglutarate + CO2 + NADPH + H+
(( (Vmax * S) ) / (Km + S)) buffer: 0.1 M Tris-HCl
PH: 7.5
Temperature: 25
uniprot:P56574 [Mn2+]

D_Isocitrate + 3_Acetylpyridine_adenine_dinucleotide_phosphate -> CO2 + Reduced_3_acetylpyridine_adenine_dinucleotide_phosphate + 2_Oxoglutarate + H+
(( (Vmax * S) ) / (Km + S)) buffer: 0.1 M Tris-HCl
PH: 7.5
Temperature: 25
uniprot:P41562 [Mn2+]

3_Acetylpyridine_adenine_dinucleotide_phosphate + D_Isocitrate -> 2_Oxoglutarate + H+ + Reduced_3_acetylpyridine_adenine_dinucleotide_phosphate + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 0.1 M Tris-HCl
PH: 7.5
Temperature: 25
uniprot:Q9XSG3 [Mn2+]

NADP+ + Isocitrate -> NADPH + 2_Oxoglutarate + H+ + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-HCl
PH: 7.4
Temperature: 25
uniprot:Q9XSG3 [Mn2+]

Isocitrate + NADP+ -> CO2 + NADPH + 2_Oxoglutarate + H+
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-HCl
PH: 7.4
Temperature: 25
uniprot:Q9XSG3 [Mn2+]

Isocitrate + NADP+ -> H+ + NADPH + 2_Oxoglutarate + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-HCl
PH: 7.4
Temperature: 25
uniprot:Q9XSG3 [Mn2+]

NADP+ + Isocitrate -> NADPH + H+ + 2_Oxoglutarate + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 100 mM Tris-HCl
PH: 7.4
Temperature: 25
uniprot:Q8I6T2 [Mn2+]

NADP+ + Isocitrate -> CO2 + NADPH + 2_Oxoglutarate + H+
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 25 mM Mops, 100 mM NaCl
PH: 8
Temperature: 30
uniprot:Q8I6T2 [Mg2+]

NADP+ + Isocitrate -> H+ + 2_Oxoglutarate + CO2 + NADPH
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 25 mM Mops, 100 mM NaCl
PH: 8
Temperature: 30
uniprot:Q8I6T2 [Mg2+]

NADP+ + Isocitrate -> 2_Oxoglutarate + NADPH + H+ + CO2
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 25 mM Mops, 100 mM NaCl
PH: 8
Temperature: 30
uniprot:Q8I6T2 [Mg2+]

NADP+ + Isocitrate -> H+ + CO2 + 2_Oxoglutarate + NADPH
(( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 25 mM Mops, 100 mM NaCl
PH: 8
Temperature: 30
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> CO2 + 2_Oxoglutarate + H+ + NADPH
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM sodium acetate (pH 5.0 - 6.2) / 30 mM imidazole chloride (pH 5.8 - 7.4) / 30 mM triethanolamine chloride (pH 6.8 - 8.0)
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> H+ + CO2 + NADPH + 2_Oxoglutarate
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM sodium acetate (pH 5.0 - 6.2) / 30 mM imidazole chloride (pH 5.8 - 7.4) / 30 mM triethanolamine chloride (pH 6.8 - 8.0)
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + CO2 + NADPH + H+
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM sodium acetate (pH 5.0 - 6.2) / 30 mM imidazole chloride (pH 5.8 - 7.4) / 30 mM triethanolamine chloride (pH 6.8 - 8.0)
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> 2_Oxoglutarate + H+ + NADPH + CO2
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM sodium acetate (pH 5.0 - 6.2) / 30 mM imidazole chloride (pH 5.8 - 7.4) / 30 mM triethanolamine chloride (pH 6.8 - 8.0)
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> H+ + CO2 + NADPH + 2_Oxoglutarate
(( (Vmax * A) ) / (Km_A + A)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> CO2 + 2_Oxoglutarate + NADPH + H+
(( (Vmax * A) ) / (Km_A + A)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> NADPH + H+ + CO2 + 2_Oxoglutarate
(( (Vmax * C) ) / (Km_C + C)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> NADPH + H+ + CO2 + 2_Oxoglutarate
(( (Vmax * B) ) / (Km_B + B)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> NADPH + H+ + CO2 + 2_Oxoglutarate
(( (Vmax * C) ) / (Km_C + C)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> H+ + NADPH + CO2 + 2_Oxoglutarate
(( (Vmax * C) ) / (Km_C + C)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> H+ + NADPH + CO2 + 2_Oxoglutarate
(( (Vmax * B) ) / (Km_B + B)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + CO2 + NADPH + H+
(( (Vmax * C) ) / (Km_C + C)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> NADPH + CO2 + H+ + 2_Oxoglutarate
(( (Vmax * A) ) / (Km_A + A)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> NADPH + H+ + 2_Oxoglutarate + CO2
(( (Vmax * B) ) / (Km_B + B)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> 2_Oxoglutarate + NADPH + CO2 + H+
(( (Vmax * B) ) / (Km_B + B)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> H+ + NADPH + 2_Oxoglutarate + CO2
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM sodium acetate (pH 5.0 - 6.2) / 30 mM imidazole chloride (pH 5.8 - 7.4) / 30 mM triethanolamine chloride (pH 6.8 - 8.0)
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> CO2 + H+ + 2_Oxoglutarate + NADPH
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM sodium acetate (pH 5.0 - 6.2) / 30 mM imidazole chloride (pH 5.8 - 7.4) / 30 mM triethanolamine chloride (pH 6.8 - 8.0)
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> NADPH + CO2 + H+ + 2_Oxoglutarate
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM sodium acetate (pH 5.0 - 6.2) / 30 mM imidazole chloride (pH 5.8 - 7.4) / 30 mM triethanolamine chloride (pH 6.8 - 8.0)
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> H+ + CO2 + 2_Oxoglutarate + NADPH
(( (Vmax * A) ) / (Km_A + A)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> 2_Oxoglutarate + NADPH + H+ + CO2
(( (Vmax * A) ) / (Km_A + A)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> H+ + CO2 + 2_Oxoglutarate + NADPH
(( (Vmax * A) ) / (Km_A + A)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> NADPH + H+ + CO2 + 2_Oxoglutarate
(( (Vmax * A) ) / (Km_A + A)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> CO2 + H+ + 2_Oxoglutarate + NADPH
(( (Vmax * A) ) / (Km_A + A)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> NADPH + CO2 + H+ + 2_Oxoglutarate
(( (Vmax * A) ) / (Km_A + A)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> H+ + 2_Oxoglutarate + NADPH + CO2
(( (Vmax * A) ) / (( (Km_A * (1 + (I / Ki))) ) + A)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + H+ + NADPH + CO2
(( (Vmax * A) ) / (( (Km_A * (1 + (I / Ki))) ) + A)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> CO2 + 2_Oxoglutarate + NADPH + H+
(( (Vmax * A) ) / (( (Km_A * (1 + (I / Ki))) ) + A)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> H+ + CO2 + 2_Oxoglutarate + NADPH
(( (Vmax * A) ) / (( (Km_A * (1 + (I / Ki))) ) + A)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + CO2 + NADPH + H+
(( (Vmax * B) ) / (Km_B + B)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> H+ + 2_Oxoglutarate + CO2 + NADPH
(( (Vmax * B) ) / (Km_B + B)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> NADPH + CO2 + 2_Oxoglutarate + H+
(( (Vmax * C) ) / (Km_C + C)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> NADPH + 2_Oxoglutarate + CO2 + H+
(( (Vmax * B) ) / (Km_B + B)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> NADPH + 2_Oxoglutarate + H+ + CO2
(( (Vmax * C) ) / (Km_C + C)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> H+ + 2_Oxoglutarate + NADPH + CO2
(( (Vmax * B) ) / (Km_B + B)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> CO2 + 2_Oxoglutarate + NADPH + H+
(( (Vmax * B) ) / (Km_B + B)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> 2_Oxoglutarate + H+ + CO2 + NADPH
(( (Vmax * B) ) / (Km_B + B)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> H+ + CO2 + NADPH + 2_Oxoglutarate
(( (Vmax * B) ) / (Km_B + B)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + NADPH + CO2 + H+
(( (Vmax * C) ) / (Km_C + C)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> NADPH + 2_Oxoglutarate + H+ + CO2
(( (Vmax * C) ) / (Km_C + C)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + H+ + CO2 + NADPH
(( (Vmax * C) ) / (Km_C + C)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> NADPH + H+ + 2_Oxoglutarate + CO2
(( (Vmax * C) ) / (Km_C + C)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> H+ + CO2 + NADPH + 2_Oxoglutarate
(( (Vmax * C) ) / (Km_C + C)) buffer: 30 mM triethanolamine hydrochloride
PH: 7.4
Temperature: 36
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + NADPH + H+ + CO2
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM triethanolamine hydrochloride
PH: 5
Temperature: 25
uniprot:P33198 [Mg2+]

NADP+ + Isocitrate -> H+ + CO2 + NADPH + 2_Oxoglutarate
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM triethanolamine hydrochloride
PH: 5
Temperature: 25
uniprot:P33198 [Cd2+]

NADP+ + Isocitrate -> CO2 + NADPH + 2_Oxoglutarate + H+
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM triethanolamine hydrochloride
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + CO2 + NADPH + H+
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM triethanolamine hydrochloride
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> NADPH + H+ + CO2 + 2_Oxoglutarate
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM triethanolamine hydrochloride
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> H+ + 2_Oxoglutarate + CO2 + NADPH
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM triethanolamine hydrochloride
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> CO2 + H+ + NADPH + 2_Oxoglutarate
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM triethanolamine hydrochloride
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> H+ + CO2 + 2_Oxoglutarate + NADPH
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM triethanolamine hydrochloride
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

Isocitrate + NADP+ -> H+ + 2_Oxoglutarate + NADPH + CO2
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM triethanolamine hydrochloride
PH: 5
Temperature: 25
uniprot:P33198 [Mn2+]

NADP+ + Isocitrate -> CO2 + H+ + 2_Oxoglutarate + NADPH
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM triethanolamine hydrochloride
PH: 5
Temperature: 25
uniprot:P33198 [Co2+]

NADP+ + Isocitrate -> CO2 + H+ + NADPH + 2_Oxoglutarate
(Vint / (1 + (( (10 ^ (0 - pH)) ) / (10 ^ (0 - pKaes))))) buffer: 30 mM triethanolamine hydrochloride
PH: 5
Temperature: 25
uniprot:P48735 [Mn2+]

NADP+ + Isocitrate -> H+ + NADPH + 2_Oxoglutarate + CO2
(( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 10 mM MOPS, 120 mM KCl, 1 mM DTT, 1 µM rotenone, 5 mM EGTA
PH: 7
Temperature: 22
uniprot:O75874 [Mn2+]

NADP+ + Isocitrate -> CO2 + H+ + 2_Oxoglutarate + NADPH
(( (Vmax * S) ) / (Km + S)) buffer: 0.05 M Tris/HCl, 0.7 mM EDTA
PH: 7.4
Temperature: 25
uniprot:O75874 [Mn2+]

Isocitrate + NADP+ -> NADPH + CO2 + 2_Oxoglutarate + H+
(( (Vmax * S) ) / (Km + S)) buffer: 0.05 M Tris/HCl, 0.7 mM EDTA
PH: 7.4
Temperature: 25
uniprot:P48735 [Mn2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + H+ + CO2 + NADPH
(( (Vmax * S) ) / (Km + S)) buffer: 0.05 M Tris/HCl, 0.7 mM EDTA
PH: 7.4
Temperature: 25
uniprot:P96083 [Mn2+]

D_threo_Isocitrate + NADP+ -> 2_Oxoglutarate + CO2 + H+ + NADPH
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M phosphate, 0.1 mM 2-mercaptoethanol
PH: 7.5
Temperature: 70
uniprot:P96083 [Mn2+]

D_threo_Isocitrate + NADP+ -> NADPH + H+ + 2_Oxoglutarate + CO2
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M phosphate, 0.1 mM 2-mercaptoethanol
PH: 7.5
Temperature: 25
uniprot:P96083 [Mn2+]

NADP+ + D_threo_Isocitrate -> H+ + NADPH + CO2 + 2_Oxoglutarate
(( (Vmax * B) ) / (Km + B)) buffer: 0.1 M phosphate, 0.1 mM 2-mercaptoethanol
PH: 7.5
Temperature: 70
uniprot:P96083 [Mn2+]

D_threo_Isocitrate + NADP+ -> NADPH + 2_Oxoglutarate + CO2 + H+
(( (Vmax * B) ) / (Km + B)) buffer: 0.1 M phosphate, 0.1 mM 2-mercaptoethanol
PH: 7.5
Temperature: 25
uniprot:P48735 [Mg2+]

Isocitrate + NADP+ -> H+ + NADPH + 2_Oxoglutarate + CO2
(( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 10 mM MOPS, 120 mM KCl, 1 mM DTT, 1 µM rotenone, 5 mM EGTA
PH: 7
Temperature: 22
uniprot:P48735 [isocitrate dehydrogenase (NADP+)(Enzyme) wildtype]

NADP+ + Isocitrate -> NADPH + CO2 + H+ + 2_Oxoglutarate
(( (Vmax * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 10 mM MOPS, 120 mM KCl, 1 mM DTT, 1 µM rotenone, 5 mM EGTA
PH: 7
Temperature: 22
uniprot:P48735 [Mn2+]

NADP+ + Isocitrate -> CO2 + NADPH + 2_Oxoglutarate + H+
(( (Vmax * S) ) / (Km + S)) buffer: 0.05 M Tris/HCl, 0.7 mM EDTA
PH: 7.4
Temperature: 25
uniprot:P33198 [Mg2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + CO2 + H+ + NADPH
(( (Vmax * A) ) / (Km + A)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:A8J9S7 [Mn2+]

D_threo_Isocitrate + NADP+ -> H+ + NADPH + 2_Oxoglutarate + CO2
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M phosphate, 0.1 mM 2-mercaptoethanol
PH: 7.5
Temperature: 25
uniprot:A8J9S7 [Mn2+]

D_threo_Isocitrate + NADP+ -> NADPH + 2_Oxoglutarate + H+ + CO2
(( (Vmax * B) ) / (Km + B)) buffer: 0.1 M phosphate, 0.1 mM 2-mercaptoethanol
PH: 7.5
Temperature: 25
uniprot:P39126 [Mn2+]

D_threo_Isocitrate + NADP+ -> NADPH + CO2 + 2_Oxoglutarate + H+
(( (Vmax * A) ) / (Km + A)) buffer: 0.1 M phosphate, 0.1 mM 2-mercaptoethanol
PH: 7.5
Temperature: 25
uniprot:P39126 [Mn2+]

D_threo_Isocitrate + NADP+ -> 2_Oxoglutarate + H+ + NADPH + CO2
(( (Vmax * B) ) / (Km + B)) buffer: 0.1 M phosphate, 0.1 mM 2-mercaptoethanol
PH: 7.5
Temperature: 25
uniprot:P33198 [Mg2+]

Isocitrate + NADP+ -> H+ + NADPH + CO2 + 2_Oxoglutarate
(( (Vmax * A) ) / (Km + A)) buffer: 30 mM triethanolamine chloride
PH: 7.4
Temperature: 25
uniprot:P33198 [Mg2+]

2_Oxoglutarate + NADPH + H+ + CO2 -> NADP+ + Isocitrate
(( (( (Vmax * A) ) * B) ) / (( (( (( (( (Kia * Kb) ) + (Ka * B)) ) + (Kb * A)) ) + (A * B)) ) + (( (A * (B ^ 2)) ) / Ki))) buffer: 33 mM imidazole-HCl, 10 µM EDTA, 300 µM dithiothreitol
PH: 6.8
Temperature: 25
uniprot:P33198 [Mg2+]

NADPH + 2_Oxoglutarate + H+ + CO2 -> Isocitrate + NADP+
(( (( (Vmax * A) ) * B) ) / (( (( (( (( (Kia * Kb) ) + (Ka * B)) ) + (Kb * A)) ) + (A * B)) ) + (( (A * (B ^ 2)) ) / Ki))) buffer: 33 mM imidazole-HCl, 10 µM EDTA, 300 µM dithiothreitol
PH: 6.8
Temperature: 25
uniprot:P33198 [Mg2+]

2_Oxoglutarate + CO2 + H+ + NADPH -> Isocitrate + NADP+
(( (( (Vmax * A) ) * B) ) / (( (( (( (( (Kia * Kb) ) + (Ka * B)) ) + (Kb * A)) ) + (A * B)) ) + (( (A * (B ^ 2)) ) / Ki))) buffer: 33 mM imidazole-HCl, 10 µM EDTA, 300 µM dithiothreitol
PH: 6.8
Temperature: 25
uniprot:P33198 [Mg2+]

NADP+ + Isocitrate -> 2_Oxoglutarate + NADPH + H+ + CO2
(( (( (Vmax * A) ) * B) ) / (( (( (( (Kia * Kb) ) + (Ka * B)) ) + (Kb * A)) ) + (A * B))) buffer: 33 mM imidazole-HCl, 10 µM EDTA, 300 µM dithiothreitol
PH: 6.8
Temperature: 25
uniprot:P33198 [Mg2+]

NADP+ + Isocitrate -> CO2 + 2_Oxoglutarate + H+ + NADPH
(( (( (Vmax * A) ) * B) ) / (( (( (( (Kia * Kb) ) + (Ka * B)) ) + (Kb * A)) ) + (A * B))) buffer: 33 mM imidazole-HCl, 10 µM EDTA, 300 µM dithiothreitol
PH: 6.8
Temperature: 25
uniprot:P33198 [Mg2+]

H+ + NADPH + CO2 + 2_Oxoglutarate -> Isocitrate + NADP+
(( (( (Vmax * A) ) * B) ) / (( (( (( (Kia * Kb) ) + (Ka * B)) ) + (Kb * A)) ) + (A * B))) buffer: 33 mM imidazole-HCl, 10 µM EDTA, 300 µM dithiothreitol
PH: 6.8
Temperature: 25
uniprot:P33198 [Mg2+]

2_Oxoglutarate + CO2 + NADPH + H+ -> NADP+ + Isocitrate
(( (( (Vmax * A) ) * B) ) / (( (( (( (( (Kia * Kb) ) + (Ka * B)) ) + (Kb * A)) ) + (A * B)) ) + (( (A * (B ^ 2)) ) / Ki))) buffer: 33 mM imidazole-HCl, 10 µM EDTA, 300 µM dithiothreitol
PH: 6.8
Temperature: 25
uniprot:P33198 [Mg2+]

NADP+ + Isocitrate -> CO2 + NADPH + H+ + 2_Oxoglutarate
(( (( (Vmax * A) ) * B) ) / (( (( (( (Kia * Kb) ) + (Ka * B)) ) + (Kb * A)) ) + (A * B))) buffer: 33 mM imidazole-HCl, 10 µM EDTA, 300 µM dithiothreitol
PH: 6.8
Temperature: 25
uniprot:P33198 [Mg2+]

2_Oxoglutarate + NADPH + H+ + CO2 -> NADP+ + Isocitrate
(( (Vmax * A) ) / (( (Ka * (1 + (I / Kis))) ) + A)) buffer: 33 mM imidazole-HCl, 10 µM EDTA, 300 µM dithiothreitol
PH: 6.8
Temperature: 25
uniprot:P33198 [Mg2+]

Isocitrate + NADP+ -> NADPH + CO2 + 2_Oxoglutarate + H+
(( (Vmax * A) ) / (( (Ka * (1 + (I / Kis))) ) + A)) buffer: 33 mM imidazole-HCl, 10 µM EDTA, 300 µM dithiothreitol
PH: 6.8
Temperature: 25
uniprot:P56574 [Mg2+]

Isocitrate + NADP+ -> 2_Oxoglutarate + CO2 + NADPH + H+
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM MOPS, 120 mM KCl, 1 mM EGTA, 0.02% Triton X-100
PH: 7.2
Temperature: 37
uniprot:P56574 [Mg2+]

NADP+ + Isocitrate -> NADPH + 2_Oxoglutarate + H+ + CO2
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM MOPS, 120 mM KCl, 1 mM EGTA, 0.02% Triton X-100
PH: 7.2
Temperature: 37
uniprot:P56574 [Mg2+]

NADP+ + Isocitrate -> 2_Oxoglutarate + NADPH + CO2 + H+
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM MOPS, 120 mM KCl, 1 mM EGTA, 0.02% Triton X-100
PH: 7.2
Temperature: 37
uniprot:P56574 [Mg2+]

Isocitrate + NADP+ -> H+ + 2_Oxoglutarate + CO2 + NADPH
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM MOPS, 120 mM KCl, 1 mM EGTA, 0.02% Triton X-100
PH: 7.2
Temperature: 37
uniprot:P56574 [Mg2+]

NADP+ + Isocitrate -> 2_Oxoglutarate + NADPH + CO2 + H+
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM MOPS, 120 mM KCl, 1 mM EGTA, 0.02% Triton X-100
PH: 7.2
Temperature: 37
uniprot:P56574 [Mg2+]

NADP+ + Isocitrate -> NADPH + 2_Oxoglutarate + CO2 + H+
(( (Vmax * S) ) / (Km + S)) buffer: 20 mM MOPS, 120 mM KCl, 1 mM EGTA, 0.02% Triton X-100
PH: 7.2
Temperature: 37

Pathways

pathway id name
BioCyc:META_PWY-6549 L-glutamine biosynthesis III
BioCyc:META_TCA-GLYOX-BYPASS superpathway of glyoxylate bypass and TCA
BioCyc:ECO_TCA-GLYOX-BYPASS superpathway of glyoxylate bypass and TCA
BioCyc:MOUSE_TCA-1 TCA cycle
BioCyc:ECOL316407_TCA TCA cycle I (prokaryotic)
BioCyc:META_PWY-7268 NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)
BioCyc:META_TCA TCA cycle I (prokaryotic)
BioCyc:ARA_PWY-6549 L-glutamine biosynthesis III
BioCyc:MTBH37RV_PWY-6969 TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)
BioCyc:HPY_REDCITCYC TCA cycle VIII (helicobacter)
BioCyc:BSUB_FERMENTATION-PWY mixed acid fermentation
BioCyc:BSUB_ANARESP1-PWY respiration (anaerobic)
BioCyc:BSUB_TCA TCA cycle I (prokaryotic)
BioCyc:ECOL316407_ANARESP1-PWY respiration (anaerobic)
BioCyc:META_PWY-6969 TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)
BioCyc:ECO_TCA TCA cycle I (prokaryotic)
BioCyc:ECO_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:YEAST_PWY-7245 superpathway NAD/NADP - NADH/NADPH interconversion
BioCyc:MTBH37RV_FERMENTATION-PWY mixed acid fermentation
BioCyc:ECOL316407_FERMENTATION-PWY mixed acid fermentation
BioCyc:ECOL316407_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:CORYNE_TCA TCA cycle I (prokaryotic)
BioCyc:CORYNE_FERMENTATION-PWY mixed acid fermentation
BioCyc:META_PWY-7245 superpathway NAD/NADP - NADH/NADPH interconversion (yeast)
BioCyc:META_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:META_FERMENTATION-PWY mixed acid fermentation
BioCyc:META_PWY-7124 ethylene biosynthesis V (engineered)
BioCyc:ECO_FERMENTATION-PWY mixed acid fermentation
BioCyc:YEAST_PWY-7268 NAD/NADP-NADH/NADPH cytosolic interconversion
BioCyc:ECOL316407_TCA-GLYOX-BYPASS superpathway of glyoxylate bypass and TCA
BioCyc:CORYNE_TCA-GLYOX-BYPASS superpathway of glyoxylate bypass and TCA
PathBank:SMP0000802 TCA Cycle
PathBank:SMP0001018 TCA cycle (ubiquinol-2)
PathBank:SMP0001019 TCA cycle (ubiquinol-3)
PathBank:SMP0001020 TCA cycle (ubiquinol-4)
PathBank:SMP0001021 TCA cycle (ubiquinol-5)
PathBank:SMP0001022 TCA cycle (ubiquinol-6)
PathBank:SMP0001023 TCA cycle (ubiquinol-7)
PathBank:SMP0001024 TCA cycle (ubiquinol-8)
PathBank:SMP0001025 TCA cycle (ubiquinol-9)
PathBank:SMP0001026 TCA cycle (ubiquinol-10)
PathBank:SMP0002037 TCA cycle (ubiquinol-0)
PlantCyc:ARA_PWY-6549 L-glutamine biosynthesis III
Reactome:R-MMU-9854311 Maturation of TCA enzymes and regulation of TCA cycle
Reactome:R-RNO-9854311 Maturation of TCA enzymes and regulation of TCA cycle
Reactome:R-HSA-9755511 KEAP1-NFE2L2 pathway
Reactome:R-BTA-9854311 Maturation of TCA enzymes and regulation of TCA cycle
Reactome:R-HSA-9711123 Cellular response to chemical stress
Reactome:R-HSA-9759194 Nuclear events mediated by NFE2L2
Reactome:R-HSA-9818025 NFE2L2 regulating TCA cycle genes
Reactome:R-HSA-9854311 Maturation of TCA enzymes and regulation of TCA cycle
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-BTA-71403 Citric acid cycle (TCA cycle)
Reactome:R-HSA-1643685 Disease
Reactome:R-MMU-1430728 Metabolism
Reactome:R-SCE-8978934 Metabolism of cofactors
Reactome:R-SPO-1430728 Metabolism
Reactome:R-DDI-196854 Metabolism of vitamins and cofactors
Reactome:R-DDI-8978934 Metabolism of cofactors
Reactome:R-HSA-196854 Metabolism of vitamins and cofactors
Reactome:R-HSA-389542 NADPH regeneration
Reactome:R-HSA-2262752 Cellular responses to stress
Reactome:R-MMU-196854 Metabolism of vitamins and cofactors
Reactome:R-MMU-389542 NADPH regeneration
Reactome:R-RNO-196854 Metabolism of vitamins and cofactors
Reactome:R-RNO-389542 NADPH regeneration
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SPO-8978934 Metabolism of cofactors
Reactome:R-DDI-389542 NADPH regeneration
Reactome:R-HSA-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-HSA-71403 Citric acid cycle (TCA cycle)
Reactome:R-HSA-8978934 Metabolism of cofactors
Reactome:R-HSA-5668914 Diseases of metabolism
Reactome:R-MMU-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-MMU-71403 Citric acid cycle (TCA cycle)
Reactome:R-MMU-8978934 Metabolism of cofactors
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-1428517 Aerobic respiration and respiratory electron transport
Reactome:R-RNO-71403 Citric acid cycle (TCA cycle)
Reactome:R-RNO-8978934 Metabolism of cofactors
Reactome:R-SPO-196854 Metabolism of vitamins and cofactors
Reactome:R-SPO-389542 NADPH regeneration
Reactome:R-DDI-1430728 Metabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-8953897 Cellular responses to stimuli
Reactome:R-HSA-2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate
Reactome:R-SCE-196854 Metabolism of vitamins and cofactors
Reactome:R-SCE-389542 NADPH regeneration
WikiPathways:WP2624 TCA cycle (Krebs cycle)
PathBank:SMP0121340 TCA Cycle (Ubiquinol-5)
PathBank:SMP0121344 TCA Cycle (Ubiquinol-9)
PathBank:SMP0002295 The Oncogenic Action of Fumarate
PathBank:SMP0002358 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria
PathBank:SMP0121339 TCA Cycle (Ubiquinol-4)
PathBank:SMP0121343 TCA Cycle (Ubiquinol-8)
PathBank:SMP0122219 TCA Cycle (Ubiquinol-0)
PathBank:SMP0002292 The Oncogenic Action of Succinate
PathBank:SMP0002403 Nitrogen Metabolism
PathBank:SMP0121269 TCA Cycle
PathBank:SMP0121337 TCA Cycle (Ubiquinol-2)
PathBank:SMP0121341 TCA Cycle (Ubiquinol-6)
PathBank:SMP0121345 TCA Cycle (Ubiquinol-10)
PathBank:SMP0000654 Warburg Effect
PathBank:SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria
PathBank:SMP0002426 Glutamine Metabolism
PathBank:SMP0121338 TCA Cycle (Ubiquinol-3)
PathBank:SMP0121342 TCA Cycle (Ubiquinol-7)
PathBank:SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate
PathBank:SMP0002298 Glutaminolysis and Cancer