neolacto-series glycosphingolipids biosynthesis

Kuan C, Chang J, Mansson J, Li J, Pegram C, Fredman P, McLendon RE, Bigner DD. Multiple phenotypic changes in mice after knockout of the B3gnt5gene, encoding Lc3 synthase—a key enzyme in lacto-neolacto ganglioside synthesis. BMC Developmental Biology. 2010 Nov 18;10(1):114. doi: 10.1186/1471-213x-10-114.; Schwientek T, Almeida R, Levery SB, Holmes EH, Bennett E, Clausen H. Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis. J Biol Chem. 1998 Nov 06;273(45):29331–40. doi: 10.1074/jbc.273.45.29331. PMID: 9792633.; Nomura T, Takizawa M, Aoki J, Arai H, Inoue K, Wakisaka E, Yoshizuka N, Imokawa G, Dohmae N, Takio K, Hattori M, Matsuo N. Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain. J Biol Chem. 1998 May 29;273(22):13570–7. doi: 10.1074/jbc.273.22.13570. PMID: 9593693.; Basu M, Weng SA, Tang H, Khan F, Rossi F, Basu S. Biosynthesis in vitro of neolactotetraosylceramide by a galactosyltransferase from mouse T-lymphoma: purification and kinetic studies; synthesis of neolacto and polylactosamine core. Glycoconj J. 1996 Jun;13(3):423–32. doi: 10.1007/bf00731475. PMID: 8781973.; Chatterjee S, Ghosh N, Khurana S. Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney. Journal of Biological Chemistry. 1992 Apr;267(10):7148–53. doi: 10.1016/s0021-9258(19)50550-6.; Chatterjee S, Castiglione E. UDPgalactose:glucosylceramide ß1 ? 4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes. Biochimica et Biophysica Acta (BBA) - General Subjects. 1987 Jan;923(1):136–42. doi: 10.1016/0304-4165(87)90136-x.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0



Enzyme

EC Number name full name note
2.4.1.-
2.4.1.149 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R 3-beta N-acetylglucosaminyltransferase (configuration-inverting)
2.4.1.206 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase
2.4.1.22 lactose synthase UDP-galactose:D-glucose 4-beta-D-galactosyltransferase
2.4.1.274 glucosylceramide beta-1,4-galactosyltransferase UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase
2.4.1.275 neolactotriaosylceramide beta-1,4-galactosyltransferase UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1beta4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase
2.4.1.38 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase
2.4.1.80 ceramide glucosyltransferase UDP-glucose:N-acylsphingosine D-glucosyltransferase
2.4.1.90 N-acetyllactosamine synthase UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
2.4.3.1 beta-galactoside alpha-(2,6)-sialyltransferase CMP-N-acetyl-beta-neuraminate:beta-D-galactoside alpha-(2->6)-N-acetylneuraminyltransferase (configuration-inverting)
2.4.3.6 N-acetyllactosaminide alpha-2,3-sialyltransferase CMP-N-acetyl-beta-neuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R (2->3)-N-acetyl-alpha-neuraminyltransferase (configuration-inverting)


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio
Homo sapiens vertebrate_mammalian 2.4.1.- / 2.4.1.149 / 2.4.1.206 / 2.4.1.22 / 2.4.1.274 / 2.4.1.275 / 2.4.1.38 / 2.4.1.80 / 2.4.1.90 / 2.4.3.1 / 2.4.3.6 100.00%
Mus musculus vertebrate_mammalian 2.4.1.- / 2.4.1.149 / 2.4.1.206 / 2.4.1.22 / 2.4.1.274 / 2.4.1.275 / 2.4.1.38 / 2.4.1.80 / 2.4.1.90 / 2.4.3.1 / 2.4.3.6 100.00%
Rattus norvegicus vertebrate_mammalian 2.4.1.- / 2.4.1.206 / 2.4.1.22 / 2.4.1.274 / 2.4.1.275 / 2.4.1.38 / 2.4.1.80 / 2.4.1.90 / 2.4.3.1 / 2.4.3.6 90.91%
Diaphorina citri invertebrate 2.4.1.- / 2.4.1.80 / 2.4.3.1 27.27%
Monascus purpureus MAGs 2.4.1.- / 2.4.1.80 18.18%
Citrus sinensis plant 2.4.1.- / 2.4.1.80 18.18%
Oryza nivara MAGs 2.4.1.- / 2.4.1.80 18.18%
Aspergillus tubingensis fungi 2.4.1.- / 2.4.1.80 18.18%
Penicillium brevicompactum fungi 2.4.1.- / 2.4.1.80 18.18%
Triticum aestivum plant 2.4.1.- / 2.4.1.80 18.18%
Aspergillus niger fungi 2.4.1.- / 2.4.1.80 18.18%
Aspergillus parasiticus MAGs 2.4.1.- / 2.4.1.80 18.18%
Penicillium canescens fungi 2.4.1.- / 2.4.1.80 18.18%
Histoplasma capsulatum fungi 2.4.1.- / 2.4.1.80 18.18%
Lachancea fermentati MAGs 2.4.1.- / 2.4.1.80 18.18%
Penicillium griseofulvum fungi 2.4.1.- / 2.4.1.80 18.18%
Aspergillus flavus fungi 2.4.1.- / 2.4.1.80 18.18%
Aspergillus oryzae fungi 2.4.1.- / 2.4.1.80 18.18%
Penicillium chrysogenum fungi 2.4.1.- / 2.4.1.80 18.18%
Exophiala dermatitidis fungi 2.4.1.- / 2.4.1.80 18.18%