neolacto-series glycosphingolipids biosynthesis
Kuan C, Chang J, Mansson J, Li J, Pegram C, Fredman P, McLendon RE, Bigner DD. Multiple phenotypic changes in mice after knockout of the B3gnt5gene, encoding Lc3 synthase—a key enzyme in lacto-neolacto ganglioside synthesis. BMC Developmental Biology. 2010 Nov 18;10(1):114. doi: 10.1186/1471-213x-10-114.; Schwientek T, Almeida R, Levery SB, Holmes EH, Bennett E, Clausen H. Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis. J Biol Chem. 1998 Nov 06;273(45):29331–40. doi: 10.1074/jbc.273.45.29331. PMID: 9792633.; Nomura T, Takizawa M, Aoki J, Arai H, Inoue K, Wakisaka E, Yoshizuka N, Imokawa G, Dohmae N, Takio K, Hattori M, Matsuo N. Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain. J Biol Chem. 1998 May 29;273(22):13570–7. doi: 10.1074/jbc.273.22.13570. PMID: 9593693.; Basu M, Weng SA, Tang H, Khan F, Rossi F, Basu S. Biosynthesis in vitro of neolactotetraosylceramide by a galactosyltransferase from mouse T-lymphoma: purification and kinetic studies; synthesis of neolacto and polylactosamine core. Glycoconj J. 1996 Jun;13(3):423–32. doi: 10.1007/bf00731475. PMID: 8781973.; Chatterjee S, Ghosh N, Khurana S. Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney. Journal of Biological Chemistry. 1992 Apr;267(10):7148–53. doi: 10.1016/s0021-9258(19)50550-6.; Chatterjee S, Castiglione E. UDPgalactose:glucosylceramide ß1 ? 4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes. Biochimica et Biophysica Acta (BBA) - General Subjects. 1987 Jan;923(1):136–42. doi: 10.1016/0304-4165(87)90136-x.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.4.1.- | |||
| 2.4.1.149 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase | UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R 3-beta N-acetylglucosaminyltransferase (configuration-inverting) | |
| 2.4.1.206 | lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase | UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase | |
| 2.4.1.22 | lactose synthase | UDP-galactose:D-glucose 4-beta-D-galactosyltransferase | |
| 2.4.1.274 | glucosylceramide beta-1,4-galactosyltransferase | UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase | |
| 2.4.1.275 | neolactotriaosylceramide beta-1,4-galactosyltransferase | UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1beta4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase | |
| 2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase | UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase | |
| 2.4.1.80 | ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | |
| 2.4.1.90 | N-acetyllactosamine synthase | UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase | |
| 2.4.3.1 | beta-galactoside alpha-(2,6)-sialyltransferase | CMP-N-acetyl-beta-neuraminate:beta-D-galactoside alpha-(2->6)-N-acetylneuraminyltransferase (configuration-inverting) | |
| 2.4.3.6 | N-acetyllactosaminide alpha-2,3-sialyltransferase | CMP-N-acetyl-beta-neuraminate:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R (2->3)-N-acetyl-alpha-neuraminyltransferase (configuration-inverting) |
Pathway Source
| Organism | Taxonomy Group | Enzyme List | Source Ratio |
|---|---|---|---|
| Homo sapiens | vertebrate_mammalian | 2.4.1.- / 2.4.1.149 / 2.4.1.206 / 2.4.1.22 / 2.4.1.274 / 2.4.1.275 / 2.4.1.38 / 2.4.1.80 / 2.4.1.90 / 2.4.3.1 / 2.4.3.6 | 100.00% |
| Mus musculus | vertebrate_mammalian | 2.4.1.- / 2.4.1.149 / 2.4.1.206 / 2.4.1.22 / 2.4.1.274 / 2.4.1.275 / 2.4.1.38 / 2.4.1.80 / 2.4.1.90 / 2.4.3.1 / 2.4.3.6 | 100.00% |
| Rattus norvegicus | vertebrate_mammalian | 2.4.1.- / 2.4.1.206 / 2.4.1.22 / 2.4.1.274 / 2.4.1.275 / 2.4.1.38 / 2.4.1.80 / 2.4.1.90 / 2.4.3.1 / 2.4.3.6 | 90.91% |
| Diaphorina citri | invertebrate | 2.4.1.- / 2.4.1.80 / 2.4.3.1 | 27.27% |
| Monascus purpureus | MAGs | 2.4.1.- / 2.4.1.80 | 18.18% |
| Citrus sinensis | plant | 2.4.1.- / 2.4.1.80 | 18.18% |
| Oryza nivara | MAGs | 2.4.1.- / 2.4.1.80 | 18.18% |
| Aspergillus tubingensis | fungi | 2.4.1.- / 2.4.1.80 | 18.18% |
| Penicillium brevicompactum | fungi | 2.4.1.- / 2.4.1.80 | 18.18% |
| Triticum aestivum | plant | 2.4.1.- / 2.4.1.80 | 18.18% |
| Aspergillus niger | fungi | 2.4.1.- / 2.4.1.80 | 18.18% |
| Aspergillus parasiticus | MAGs | 2.4.1.- / 2.4.1.80 | 18.18% |
| Penicillium canescens | fungi | 2.4.1.- / 2.4.1.80 | 18.18% |
| Histoplasma capsulatum | fungi | 2.4.1.- / 2.4.1.80 | 18.18% |
| Lachancea fermentati | MAGs | 2.4.1.- / 2.4.1.80 | 18.18% |
| Penicillium griseofulvum | fungi | 2.4.1.- / 2.4.1.80 | 18.18% |
| Aspergillus flavus | fungi | 2.4.1.- / 2.4.1.80 | 18.18% |
| Aspergillus oryzae | fungi | 2.4.1.- / 2.4.1.80 | 18.18% |
| Penicillium chrysogenum | fungi | 2.4.1.- / 2.4.1.80 | 18.18% |
| Exophiala dermatitidis | fungi | 2.4.1.- / 2.4.1.80 | 18.18% |