Complex I biogenesis
Laube E, Schiller J, Zickermann V, Vonck J. Using cryo-EM to understand the assembly pathway of respiratory complex I. Acta Crystallogr D Struct Biol. 2024 Mar 01;80(Pt 3):159–73. PMID: 38372588; PMCID: PMC10910544.; Andrews B, Carroll J, Ding S, Fearnley IM, Walker JE. Assembly factors for the membrane arm of human complex I. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18934–9. PMID: 24191001; PMCID: PMC3839705.; Mimaki M, Wang X, McKenzie M, Thorburn DR, Ryan MT. Understanding mitochondrial complex I assembly in health and disease. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2012 Jun;1817(6):851–62. doi: 10.1016/j.bbabio.2011.08.010.; Mckenzie M, Ryan MT. Assembly factors of human mitochondrial complex I and their defects in disease. IUBMB Life. 2010 Jul;62(7):497–502. doi: 10.1002/iub.335. PMID: 20552642.; Fontanesi F, Soto IC, Horn D, Barrientos A. Assembly of mitochondrial cytochrome c-oxidase, a complicated and highly regulated cellular process. American Journal of Physiology-Cell Physiology. 2006 Dec;291(6):C1129–47. doi: 10.1152/ajpcell.00233.2006.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.-.-.- | |||
| 1.3.8.7 | medium-chain acyl-CoA dehydrogenase | medium-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase | |
| 1.3.8.8 | long-chain acyl-CoA dehydrogenase | long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase | |
| 2.1.1.320 | type II protein arginine methyltransferase | S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming) | |
| 3.6.4.10 | non-chaperonin molecular chaperone ATPase | ATP phosphohydrolase (polypeptide-polymerizing) | |
| 7.1.1.2 | NADH:ubiquinone reductase (H+-translocating) | NADH:ubiquinone oxidoreductase |
Pathway Source
| Organism | Taxonomy Group | Enzyme List | Source Ratio |
|---|---|---|---|
| Knufia peltigerae | MAGs | 1.-.-.- / 1.3.8.7 / 1.3.8.8 / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 100.00% |
| Rattus norvegicus | vertebrate_mammalian | 1.-.-.- / 1.3.8.7 / 1.3.8.8 / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 100.00% |
| Mus musculus | vertebrate_mammalian | 1.-.-.- / 1.3.8.7 / 1.3.8.8 / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 100.00% |
| Homo sapiens | vertebrate_mammalian | 1.-.-.- / 1.3.8.7 / 1.3.8.8 / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 100.00% |
| Penicillium ucsense | MAGs | 1.-.-.- / 1.3.8.7 / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 83.33% |
| Rasamsonia emersonii CBS 393.64 | MAGs | 1.-.-.- / 1.3.8.7 / 1.3.8.8 / 2.1.1.320 / 3.6.4.10 | 83.33% |
| Emydomyces testavorans | MAGs | 1.-.-.- / 1.3.8.7 / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 83.33% |
| Oryza sativa Indica Group | MAGs | 1.-.-.- / 1.3.8.7 / 1.3.8.8 / 2.1.1.320 / 7.1.1.2 | 83.33% |
| Aspergillus oryzae | fungi | 1.-.-.- / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 66.67% |
| Phytophthora citrophthora | MAGs | 1.3.8.7 / 1.3.8.8 / 2.1.1.320 / 7.1.1.2 | 66.67% |
| Penicillium expansum | fungi | 1.-.-.- / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 66.67% |
| Aspergillus flavus | fungi | 1.-.-.- / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 66.67% |
| Aspergillus tubingensis | fungi | 1.-.-.- / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 66.67% |
| Penicillium chrysogenum | fungi | 1.-.-.- / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 66.67% |
| Aspergillus niger | fungi | 1.-.-.- / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 66.67% |
| Monascus purpureus | MAGs | 1.-.-.- / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 66.67% |
| Trichophyton rubrum | fungi | 1.-.-.- / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 66.67% |
| Histoplasma capsulatum | fungi | 1.-.-.- / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 66.67% |
| Aspergillus parasiticus | MAGs | 1.-.-.- / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 66.67% |
| Penicillium brevicompactum | fungi | 1.-.-.- / 2.1.1.320 / 3.6.4.10 / 7.1.1.2 | 66.67% |