superpathway of sterol biosynthesis

Ginger ML, Chance ML, Sadler IH, Goad LJ. The Biosynthetic Incorporation of the Intact Leucine Skeleton into Sterol by the Trypanosomatid Leishmania mexicana. Journal of Biological Chemistry. 2001 Apr;276(15):11674–82. doi: 10.1074/jbc.m006850200.; Ginger ML, Prescott MC, Reynolds DG, Chance ML, Goad LJ. Utilization of leucine and acetate as carbon sources for sterol and fatty acid biosynthesis by Old and New World Leishmania species, Endotrypanum monterogeii and Trypanosoma cruzi. European Journal of Biochemistry. 2000 May;267(9):2555–66. doi: 10.1046/j.1432-1327.2000.01261.x.

Metabolites

(R)-5-Diphosphomevalonate

Formula: C6H14O10P2 (308.0062204)

CAS ID: 103025-21-4

(R)-5-Phosphomevalonate

Formula: C6H13O7P (228.0398878)

CAS ID: 73566-35-5

(S)-2,3-Epoxysqualene

Formula: C30H50O (426.386145)

CAS ID: 54910-48-4

(S)-3-Hydroxy-3-methylglutaryl-CoA

Formula: C27H44N7O20P3S (911.1574614)

CAS ID: 1553-55-5

3-Methylbutanoyl-CoA

Formula: C26H44N7O17P3S (851.1727164)

CAS ID: 6244-91-3

3-Methylcrotonyl-CoA

Formula: C26H42N7O17P3S (849.1570672000001)

CAS ID: 6712-03-4

4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol

Formula: C29H46O (410.3548466)

CAS ID: 64284-64-6

7-Dehydrodesmosterol

Formula: C27H42O (382.3235482)

CAS ID: 1715-86-2

Acetoacetyl-CoA

Formula: C25H40N7O18P3S (851.136333)

CAS ID: 1420-36-6

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Dimethylallyl diphosphate

Formula: C5H12O7P2 (246.0058262)

CAS ID: 358-72-5

Ergosterol

Formula: C28H44O (396.3391974)

CAS ID: 57-87-4

Fecosterol

Formula: C28H46O (398.3548466)

CAS ID: 516-86-9

Formate

Formula: CH2O2 (46.0054792)

CAS ID: 64-18-6

Geranyl diphosphate

Formula: C10H20O7P2 (314.068423)

CAS ID: 763-10-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

Isopentenyl diphosphate

Formula: C5H12O7P2 (246.0058262)

CAS ID: 358-71-4

L-Leucine

Formula: C6H13NO2 (131.0946238)

CAS ID: 61-90-5

Lanosterol

Formula: C30H50O (426.386145)

CAS ID: 79-63-0

NADH

Formula: C21H29N7O14P2 (665.1247674)

CAS ID: 58-68-4

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

NADPH

Formula: C21H30N7O17P3 (745.0911)

CAS ID: 2646-71-1

Orthophosphate

Formula: H3PO4 (97.9768968)

CAS ID: 7664-38-2

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

S-Adenosyl-L-homocysteine

Formula: C14H20N6O5S (384.12158300000004)

CAS ID: 979-92-0

S-Adenosyl-L-methionine

Formula: C15H22N6O5S (398.1372322)

CAS ID: 29908-03-0

Squalene

Formula: C30H50 (410.39123)

CAS ID: 111-02-4

trans,trans-Farnesyl diphosphate

Formula: C15H28O7P2 (382.1310198)

CAS ID: 372-97-4

Zymosterol

Formula: C27H44O (384.3391974)

CAS ID: 128-33-6

acetoacetate

Formula: C4H5O3 (101.02386800000001)

CAS ID: 141-81-1

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

4-methyl-2-oxopentanoate

Formula: C6H9O3 (129.05516640000002)

CAS ID:

(R)-mevalonate

Formula: C6H11O4 (147.0657306)

CAS ID: 1192-42-3

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9



Enzyme

EC Number name full name note


Pathway Source

Organism Taxonomy Group Enzyme List Source Ratio