3-Iodo-L-tyrosine (BioCAD00000003605)

blood thyroid gland

Metabolite Card

Chinese Name: 3-碘-L-酪氨酸
Formula: C9H10INO3 (306.9705)
SMILES: 

N[C@@H](CC1=CC=C(O)C(I)=C1)C(O)=O

Synonyms [en]

3-iodo-L-tyrosine; IODOTYROSINE; 3-iodotyrosine; (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoate; 3-Iodo-4-hydroxyphenylalanine; (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid

Reviewed

Last reviewed on 2026-04-16.

Cite this Page

3-Iodo-L-tyrosine. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/3-Iodo-L-tyrosine (retrieved 2026-08-20) (CAD Registry RN: BioCAD00000003605). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Iodotyrosine is an iodated derivative of L-tyrosine. This is an early precursor to L-thyroxine, one of the primary thyroid hormones. In the thyroid gland, iodide is trapped, transported, and concentrated in the follicular lumen for thyroid hormone synthesis. Before trapped iodide can react with tyrosine residues, it must be oxidized by thyroid peroxidase. Iodotyrosine is made from tyrosine via thyroid peroxidase and then further iodinated by this enzyme to make the di-iodo and tri-iodo variants. Two molecules of di-iodotyrosine combine to form T4, and one molecule of mono-iodotyrosine combines with one molecule of di-iodotyrosine to form T3.

Cytoplasm
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 3078-39-5
  • CAS Registry Number: 70-78-0
  • PubChem: 439744
  • PubChem: 5525
  • PubChem: 6272
  • ChEBI: ChEBI:27847
  • HMDB: HMDB0000021
  • KEGG: C02515
  • BioCyc: CPD-12288
  • NCBI MeSH: 3-iodotyrosine
  • Wikipedia: 3-Iodotyrosine
  • DrugBank: DB01758
  • RefMet: RM0132209
  • MoNA: HMDB0000021_c_ms_1887
  • MoNA: HMDB0000021_c_ms_1890
  • MoNA: HMDB0000021_ms_ms_36
  • MoNA: HMDB0000021_ms_ms_37
  • MoNA: HMDB0000021_ms_ms_38
  • MoNA: KO001241
  • MoNA: KO001242
  • MoNA: KO001243
  • MoNA: KO001244
  • MoNA: KO001245
  • MoNA: KO003227
  • MoNA: KO003228
  • MoNA: KO003229
  • MoNA: KO003230
  • MoNA: KO003231
  • MoNA: KO009006
  • MoNA: KO009007
  • MoNA: KO009008
  • MoNA: KO009009
  • MoNA: KO009010
  • MoNA: KO009011
  • MoNA: KO009012
  • MoNA: KO009013
  • MoNA: MoNA_0004810
  • Metlin: METLIN_1008
  • Coconut NaturalProduct: CNP0354293.1
  • PMHub: MS000000657
  • metaboanalyst: 1c1749f9df9918984fd9228b92deed82
  • metaboanalyst: 38ed35c9af2fc486c65f959c7644f5fe
  • metaboanalyst: 85ba92d2acd975dd940f27583d967047

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R03539 1.11.1.8 C05590 + C02515<=>C01382 + C00082
KEGG:R03953 1.11.1.8 C02515 + C01060 + C00027<=>C02465 + C02218 + 2 C00001
KEGG:R03973 1.11.1.8 C05590 + C01060<=>C02515 + C01382
KEGG:R09521 1.21.1.1 L-tyrosine,iodide:NADP+ oxidoreductase (iodinating)
KEGG:R09522 1.21.1.1 L-tyrosine,iodide:NADP+ oxidoreductase (iodinating)
BioCyc:RXN-11330 3-iodo-L-tyrosine deiodinase
BioCyc:RXN-11331 3,5-diiodo-L-tyrosine deiodinase
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Mass Spectrum
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View All Mass Spectrum
Organism Source

Taxonomy Source

  1. Homo sapiens [ncbi taxid: 9606]
  2. Mus musculus [ncbi taxid: 10090]

Pathway Synthetic

pathway id name
Reactome:R-BTA-1430728 Metabolism
Reactome:R-BTA-71291 Amino acid and derivative metabolism
Reactome:R-BTA-209968 Thyroxine biosynthesis
Reactome:R-CEL-209968 Thyroxine biosynthesis
Reactome:R-CFA-1430728 Metabolism
Reactome:R-DRE-71291 Amino acid and derivative metabolism
Reactome:R-DRE-209968 Thyroxine biosynthesis
Reactome:R-DME-209776 Metabolism of amine-derived hormones
Reactome:R-MMU-1430728 Metabolism
Reactome:R-CFA-71291 Amino acid and derivative metabolism
Reactome:R-CFA-209968 Thyroxine biosynthesis
Reactome:R-DME-1430728 Metabolism
Reactome:R-DME-71291 Amino acid and derivative metabolism
Reactome:R-GGA-71291 Amino acid and derivative metabolism
Reactome:R-GGA-209968 Thyroxine biosynthesis
Reactome:R-HSA-209776 Metabolism of amine-derived hormones
Reactome:R-MMU-209776 Metabolism of amine-derived hormones
Reactome:R-RNO-209776 Metabolism of amine-derived hormones
Reactome:R-SSC-1430728 Metabolism
Reactome:R-SSC-209776 Metabolism of amine-derived hormones
View All Pathways