S-Adenosylmethionine (BioCAD00000019906)
blood cerebrospinal fluid (csf) feces urine epidermis eye lens fibroblasts intestine kidney neuron ovary placenta prostate skeletal muscle testis
Metabolite Card
Chinese Name: S-腺苷-L-蛋氨酸
Formula: C15H23N6O5S (399.1451)
SMILES:
C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2NSynonyms [en]
S-adenosylmethionine; AdoMet; SAM; S-(5'-deoxyadenosin-5'-yl)-L-methionine; S-adenosyl-L-methionine; (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
Note
S-Adenosylmethionine (CAS: 29908-03-0), also known as SAM or AdoMet, is a physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in the treatment of chronic liver disease (From Merck, 11th ed). S-Adenosylmethionine is a natural substance present in the cells of the body. It plays a crucial biochemical role by donating a one-carbon methyl group in a process called transmethylation. S-Adenosylmethionine, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine, and other molecules.
DBLinks
- CAS Registry Number: 485-80-3
- PubChem CID: 34756
- ChEBI: 15414
- HMDB: HMDB0001185
- LipidMaps:
- KEGG: C00019
- BioCyc: S-ADENOSYLMETHIONINE
- NCBI MeSH: S-Adenosylmethionine
- Wikipedia: S-Adenosyl_methionine
Other DBLinks
- CAS Registry Number: 14031-35-7
- CAS Registry Number: 29908-03-0
- CAS Registry Number: 485-80-3
- PubChem: 24762165
- PubChem: 3321
- PubChem: 34756
- ChEBI: ChEBI:142093
- ChEBI: ChEBI:15414
- HMDB: HMDB0001185
- KEGG: C00019
- BioCyc: S-ADENOSYLMETHIONINE
- NCBI MeSH: S-Adenosylmethionine
- Wikipedia: S-Adenosyl_methionine
- DrugBank: DB00118
- RefMet: RM0138941
- MoNA: KO002073
- MoNA: KO002074
- MoNA: KO002075
- MoNA: KO002076
- MoNA: KO002077
- MoNA: KO008827
- MoNA: KO008828
- Coconut NaturalProduct: CNP0085538.1
- Coconut NaturalProduct: CNP0085538.2
- Coconut NaturalProduct: CNP0085538.3
- metaboanalyst: f27b51d33a9fae93d1f33b860d14bc2b
Class / Ontology
- WishartLab ClassyFire: [5'-deoxy-5'-thionucleosides] 5'-deoxy-5'-thionucleosides
- RefMet: [Other purines] Other purines
- ChEBI: [CHEBI:15414] S-adenosyl-L-methionine
- Coconut NaturalProduct: [Purine nucleos(t)ides] Purine nucleos(t)ides
Taxonomy Source
Pathway Synthetic
| pathway id | name |
|---|---|
| BioCyc:CALBI_PWY-5041 | S-adenosylmethionine cycle |
| BioCyc:CALBI_BIOTIN-SYNTHESIS-PWY | biotin biosynthesis |
| BioCyc:CALBI_ERGOSTEROL-SYN-PWY | superpathway of ergosterol biosynthesis |
| BioCyc:CALBI_POLYAMSYN-YEAST-PWY | polyamine biosynthesis |
| BioCyc:CALBI_PWY3B3-10 | ubiquinone (coenzyme Q) biosynthesis |
| BioCyc:CALBI_PHOSLIPSYN2-PWY | phospholipid biosynthesis |
| BioCyc:CALBI_PWY-5194 | siroheme biosynthesis |
| BioCyc:CALBI_PWY-6075 | ergosterol biosynthesis |
| Plant Reactome:R-HVU-1119370 | Sterol biosynthesis |
| Plant Reactome:R-OAU-2744345 | Metabolism and regulation |
| Plant Reactome:R-OAU-2744343 | Amino acid metabolism |
| Plant Reactome:R-OAU-1119349 | SMM cycle |
| Plant Reactome:R-OAU-1119334 | Ethene biosynthesis from methionine |
| Plant Reactome:R-OAU-9609573 | Tricin biosynthesis |
| Plant Reactome:R-OAU-9025714 | Response to iron deficiency |
| Plant Reactome:R-CME-1119624 | Yang cycle |
| Plant Reactome:R-CME-5096066 | Amine and polyamine biosynthesis |
| Plant Reactome:R-CME-1119610 | Biotin biosynthesis II |
| Plant Reactome:R-CME-2744341 | Hormone signaling, transport, and metabolism |
| Plant Reactome:R-CME-5368291 | Inorganic nutrients metabolism |