18-Oxocortisol (BioCAD00000019603)
Metabolite Card
Chinese Name:
Formula: C21H28O6 (376.1886)
SMILES:
[H][C@@]12CC[C@@](O)(C(=O)CO)[C@]1(C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C)C=OSynonyms [en]
18-Oxocortisol; 11 beta,17 alpha,21-Trihydroxy-3,20-diketo-4-pregnene-18-al; (1S,2R,10S,11S,14S,15R,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-ene-15-carbaldehyde; (11beta)-11,17,21-trihydroxy-3,20-dioxopregn-4-en-18-al; (8~{S},9~{S},10~{R},11~{S},13~{R},14~{S},17~{S})-11,17-dihydroxy-17-(2-hydroxyacetyl)-10-methyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1~{H}-cyclopenta[a]phenanthrene-13-carbaldehyde; SCHEMBL144491
Last reviewed on 2026-04-16.
Cite this Page
18-Oxocortisol. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China.
https://biocad_registry.innovation.ac.cn/s/18-Oxocortisol
(retrieved
2026-08-20) (CAD Registry RN: BioCAD00000019603). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Note
18-Oxocortisol shares structural characteristics with cortisol and aldosterone and is secreted from the adrenal cortex. The plasma levels of 18-Oxocortisol are significantly higher in patients with adrenocortical disorders than in control subjects. (PMID 8013138).
DBLinks
- CAS Registry Number: 2410-60-8
- PubChem CID: 44263344
- ChEBI: 89213
- HMDB: HMDB0000332
- LipidMaps: LMST02030194
- KEGG:
- BioCyc:
- NCBI MeSH: 18-oxocortisol
- Wikipedia: 18-Oxocortisol
Other DBLinks
- CAS Registry Number: 2410-60-8
- PubChem: 129628208
- PubChem: 44263344
- ChEBI: ChEBI:89213
- HMDB: HMDB0000332
- HMDB: HMDB00332
- LipidMaps: LMST02030194
- LipidMaps: LMST02030296
- NCBI MeSH: 18-oxocortisol
- Wikipedia: 18-Oxocortisol
- RefMet: RM0135787
- Metlin: METLIN_5321
- Coconut NaturalProduct: CNP0282900.1
Class / Ontology
- WishartLab ClassyFire: [Hydroxysteroids] Hydroxysteroids
- RefMet: [C21 steroids] C21 steroids
- LipidMaps: [C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives [ST0203]] C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives [ST0203]
- ChEBI: [CHEBI:89213] 18-oxocortisol
- Coconut NaturalProduct: [Pregnane steroids] Pregnane steroids
| ID | EC Number | Name |
|---|---|---|
| Rhea:RHEA:76024 | 18-hydroxycortisol + 2 reduced [adrenodoxin] + O2 + 2 H+ => 18-oxocortisol + 2 oxidized [adrenodoxin] + 2 H2O | |
| Rhea:RHEA:76025 | 18-oxocortisol + 2 oxidized [adrenodoxin] + 2 H2O => 18-hydroxycortisol + 2 reduced [adrenodoxin] + O2 + 2 H+ | |
| Rhea:RHEA:76026 | 18-hydroxycortisol + 2 reduced [adrenodoxin] + O2 + 2 H+ <=> 18-oxocortisol + 2 oxidized [adrenodoxin] + 2 H2O | |
| Rhea:RHEA:76023 | [76023] 18-hydroxycortisol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 18-oxocortisol + 2 oxidized [adrenodoxin] + 2 H2O |