EC: 5.6.2.3

DNA 5'-3' helicase (DNA 5'-3' helicase (ATP-hydrolysing))

enzyme lambda metabolic reaction experiment

Pathways

pathway id name
WikiPathways:WP2472 Escherichia coli K-12 peripherome
Reactome:R-HSA-9675135 Diseases of DNA repair
Reactome:R-HSA-9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Reactome:R-HSA-9709570 Impaired BRCA2 binding to RAD51
Reactome:R-HSA-9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Reactome:R-HSA-9675136 Diseases of DNA Double-Strand Break Repair
Reactome:R-HSA-9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function
Reactome:R-HSA-9709603 Impaired BRCA2 binding to PALB2
Reactome:R-HSA-9824446 Viral Infection Pathways
Reactome:R-HSA-9701193 Defective homologous recombination repair (HRR) due to PALB2 loss of function
Reactome:R-HSA-9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Reactome:R-HSA-9913635 Strand-asynchronous mitochondrial DNA replication
Reactome:R-MMU-9913635 Strand-asynchronous mitochondrial DNA replication
Reactome:R-DME-9913635 Strand-asynchronous mitochondrial DNA replication
Reactome:R-SPO-73864 RNA Polymerase I Transcription
Reactome:R-SPO-73772 RNA Polymerase I Promoter Escape
Reactome:R-DDI-73772 RNA Polymerase I Promoter Escape
Reactome:R-SPO-73854 RNA Polymerase I Promoter Clearance
Reactome:R-SCE-73772 RNA Polymerase I Promoter Escape
Reactome:R-BTA-74160 Gene expression (Transcription)
Reactome:R-BTA-73762 RNA Polymerase I Transcription Initiation
Reactome:R-BTA-73857 RNA Polymerase II Transcription
Reactome:R-BTA-3700989 Transcriptional Regulation by TP53
Reactome:R-BTA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
Reactome:R-BTA-77075 RNA Pol II CTD phosphorylation and interaction with CE
Reactome:R-BTA-5696398 Nucleotide Excision Repair
Reactome:R-BTA-5696400 Dual Incision in GG-NER
Reactome:R-BTA-6782135 Dual incision in TC-NER
Reactome:R-DDI-73894 DNA Repair
Reactome:R-DDI-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
Reactome:R-DDI-6781823 Formation of TC-NER Pre-Incision Complex
Reactome:R-DDI-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
Reactome:R-DDI-75955 RNA Polymerase II Transcription Elongation
Reactome:R-GGA-5693532 DNA Double-Strand Break Repair
Reactome:R-GGA-5693538 Homology Directed Repair
Reactome:R-GGA-5693579 Homologous DNA Pairing and Strand Exchange
Reactome:R-HSA-5693532 DNA Double-Strand Break Repair
Reactome:R-HSA-5693538 Homology Directed Repair
Reactome:R-HSA-5693579 Homologous DNA Pairing and Strand Exchange
Reactome:R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Reactome:R-HSA-5696398 Nucleotide Excision Repair
Reactome:R-HSA-5696400 Dual Incision in GG-NER
Reactome:R-HSA-6782135 Dual incision in TC-NER
Reactome:R-HSA-73886 Chromosome Maintenance
Reactome:R-HSA-180786 Extension of Telomeres
Reactome:R-HSA-381070 IRE1alpha activates chaperones
Reactome:R-HSA-1643685 Disease
Reactome:R-HSA-162587 HIV Life Cycle
Reactome:R-HSA-167172 Transcription of the HIV genome
Reactome:R-HSA-167169 HIV Transcription Elongation
Reactome:R-HSA-74160 Gene expression (Transcription)
Reactome:R-HSA-73762 RNA Polymerase I Transcription Initiation
Reactome:R-HSA-73857 RNA Polymerase II Transcription
Reactome:R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
Reactome:R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
Reactome:R-HSA-75955 RNA Polymerase II Transcription Elongation
Reactome:R-MMU-1640170 Cell Cycle
Reactome:R-MMU-5693607 Processing of DNA double-strand break ends
Reactome:R-MMU-5693537 Resolution of D-Loop Structures
Reactome:R-MMU-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Reactome:R-MMU-8953854 Metabolism of RNA
Reactome:R-MMU-74160 Gene expression (Transcription)
Reactome:R-MMU-73762 RNA Polymerase I Transcription Initiation
Reactome:R-MMU-73857 RNA Polymerase II Transcription
Reactome:R-MMU-3700989 Transcriptional Regulation by TP53
Reactome:R-MMU-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
Reactome:R-MMU-77075 RNA Pol II CTD phosphorylation and interaction with CE
Reactome:R-RNO-157579 Telomere Maintenance
Reactome:R-SCE-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome:R-SCE-72086 mRNA Capping
Reactome:R-SCE-73854 RNA Polymerase I Promoter Clearance
Reactome:R-SCE-3700989 Transcriptional Regulation by TP53
Reactome:R-SCE-6796648 TP53 Regulates Transcription of DNA Repair Genes
Reactome:R-SCE-75953 RNA Polymerase II Transcription Initiation
Reactome:R-SCE-113418 Formation of the Early Elongation Complex
Reactome:R-SPO-72086 mRNA Capping
Reactome:R-SPO-3700989 Transcriptional Regulation by TP53
Reactome:R-SPO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
Reactome:R-SPO-75955 RNA Polymerase II Transcription Elongation
Reactome:R-SPO-5696395 Formation of Incision Complex in GG-NER
Reactome:R-SPO-6781823 Formation of TC-NER Pre-Incision Complex
Reactome:R-BTA-6796648 TP53 Regulates Transcription of DNA Repair Genes
Reactome:R-BTA-674695 RNA Polymerase II Pre-transcription Events
Reactome:R-BTA-73776 RNA Polymerase II Promoter Escape
Reactome:R-BTA-73894 DNA Repair
Reactome:R-BTA-5696395 Formation of Incision Complex in GG-NER
Reactome:R-BTA-6781823 Formation of TC-NER Pre-Incision Complex
Reactome:R-DDI-5696398 Nucleotide Excision Repair
Reactome:R-DDI-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Reactome:R-DDI-73854 RNA Polymerase I Promoter Clearance
Reactome:R-DDI-3700989 Transcriptional Regulation by TP53
Reactome:R-DDI-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
Reactome:R-DDI-77075 RNA Pol II CTD phosphorylation and interaction with CE
Reactome:R-GGA-351465 Fanconi Anemia Pathway in DNA repair
Reactome:R-GGA-5685942 HDR through Homologous Recombination (HRR)
Reactome:R-GGA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
Reactome:R-HSA-1592230 Mitochondrial biogenesis
Reactome:R-HSA-2564830 Cytosolic iron-sulfur cluster assembly
Reactome:R-HSA-5685942 HDR through Homologous Recombination (HRR)
Reactome:R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
Reactome:R-HSA-5696395 Formation of Incision Complex in GG-NER
Reactome:R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
Reactome:R-HSA-2262752 Cellular responses to stress
Reactome:R-HSA-1640170 Cell Cycle
Reactome:R-HSA-157579 Telomere Maintenance
Reactome:R-HSA-162906 HIV Infection
Reactome:R-HSA-162599 Late Phase of HIV Life Cycle
Reactome:R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
Reactome:R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
Reactome:R-HSA-69306 DNA Replication
Reactome:R-HSA-73863 RNA Polymerase I Transcription Termination
Reactome:R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
Reactome:R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE
Reactome:R-HSA-212165 Epigenetic regulation of gene expression
Reactome:R-HSA-427413 NoRC negatively regulates rRNA expression
Reactome:R-MMU-171319 Telomere Extension By Telomerase
Reactome:R-MMU-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-MMU-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
Reactome:R-MMU-5685938 HDR through Single Strand Annealing (SSA)
Reactome:R-MMU-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
Reactome:R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome:R-MMU-6796648 TP53 Regulates Transcription of DNA Repair Genes
Reactome:R-MMU-674695 RNA Polymerase II Pre-transcription Events
Reactome:R-MMU-73776 RNA Polymerase II Promoter Escape
Reactome:R-MMU-112382 Formation of RNA Pol II elongation complex
Reactome:R-RNO-1640170 Cell Cycle
Reactome:R-SCE-5696398 Nucleotide Excision Repair
Reactome:R-SCE-6782135 Dual incision in TC-NER
Reactome:R-SCE-8953854 Metabolism of RNA
Reactome:R-SCE-73864 RNA Polymerase I Transcription
Reactome:R-SCE-212436 Generic Transcription Pathway
Reactome:R-SCE-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
Reactome:R-SCE-75955 RNA Polymerase II Transcription Elongation
Reactome:R-SPO-8953854 Metabolism of RNA
Reactome:R-SPO-69306 DNA Replication
Reactome:R-SPO-69166 Removal of the Flap Intermediate
Reactome:R-SPO-1640170 Cell Cycle
Reactome:R-SPO-69242 S Phase
Reactome:R-SPO-212436 Generic Transcription Pathway
Reactome:R-SPO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
Reactome:R-SPO-77075 RNA Pol II CTD phosphorylation and interaction with CE
Reactome:R-SPO-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
Reactome:R-SPO-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Reactome:R-BTA-73864 RNA Polymerase I Transcription
Reactome:R-BTA-73772 RNA Polymerase I Promoter Escape
Reactome:R-BTA-212436 Generic Transcription Pathway
Reactome:R-BTA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
Reactome:R-BTA-75955 RNA Polymerase II Transcription Elongation
Reactome:R-BTA-8953854 Metabolism of RNA
Reactome:R-BTA-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
Reactome:R-BTA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome:R-DDI-6782135 Dual incision in TC-NER
Reactome:R-DDI-74160 Gene expression (Transcription)
Reactome:R-DDI-73857 RNA Polymerase II Transcription
Reactome:R-DDI-6796648 TP53 Regulates Transcription of DNA Repair Genes
Reactome:R-DDI-75953 RNA Polymerase II Transcription Initiation
Reactome:R-DDI-113418 Formation of the Early Elongation Complex
Reactome:R-DDI-8953854 Metabolism of RNA
Reactome:R-DME-69306 DNA Replication
Reactome:R-GGA-1670466 DNA replication and repair
Reactome:R-GGA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-GGA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
Reactome:R-GGA-5685938 HDR through Single Strand Annealing (SSA)
Reactome:R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
Reactome:R-HSA-5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome:R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange
Reactome:R-HSA-5685938 HDR through Single Strand Annealing (SSA)
Reactome:R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
Reactome:R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome:R-HSA-171319 Telomere Extension By Telomerase
Reactome:R-HSA-381119 Unfolded Protein Response (UPR)
Reactome:R-HSA-381038 XBP1(S) activates chaperone genes
Reactome:R-HSA-167161 HIV Transcription Initiation
Reactome:R-HSA-167158 Formation of the HIV-1 Early Elongation Complex
Reactome:R-HSA-73864 RNA Polymerase I Transcription
Reactome:R-HSA-73772 RNA Polymerase I Promoter Escape
Reactome:R-HSA-212436 Generic Transcription Pathway
Reactome:R-HSA-3700989 Transcriptional Regulation by TP53
Reactome:R-HSA-75953 RNA Polymerase II Transcription Initiation
Reactome:R-HSA-113418 Formation of the Early Elongation Complex
Reactome:R-HSA-5250941 Negative epigenetic regulation of rRNA expression
Reactome:R-HSA-8953854 Metabolism of RNA
Reactome:R-MMU-157579 Telomere Maintenance
Reactome:R-MMU-73894 DNA Repair
Reactome:R-MMU-5685942 HDR through Homologous Recombination (HRR)
Reactome:R-MMU-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
Reactome:R-MMU-5696395 Formation of Incision Complex in GG-NER
Reactome:R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
Reactome:R-MMU-72086 mRNA Capping
Reactome:R-MMU-73864 RNA Polymerase I Transcription
Reactome:R-MMU-73772 RNA Polymerase I Promoter Escape
Reactome:R-MMU-212436 Generic Transcription Pathway
Reactome:R-MMU-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
Reactome:R-MMU-75955 RNA Polymerase II Transcription Elongation
Reactome:R-RNO-73886 Chromosome Maintenance
Reactome:R-RNO-180786 Extension of Telomeres
Reactome:R-SCE-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Reactome:R-SCE-674695 RNA Polymerase II Pre-transcription Events
Reactome:R-SCE-73776 RNA Polymerase II Promoter Escape
Reactome:R-SPO-69239 Synthesis of DNA
Reactome:R-SPO-69186 Lagging Strand Synthesis
Reactome:R-SPO-74160 Gene expression (Transcription)
Reactome:R-SPO-6796648 TP53 Regulates Transcription of DNA Repair Genes
Reactome:R-SPO-75953 RNA Polymerase II Transcription Initiation
Reactome:R-SPO-113418 Formation of the Early Elongation Complex
Reactome:R-SPO-5696400 Dual Incision in GG-NER
Reactome:R-SPO-6782135 Dual incision in TC-NER
Reactome:R-BTA-73854 RNA Polymerase I Promoter Clearance
Reactome:R-BTA-75953 RNA Polymerase II Transcription Initiation
Reactome:R-BTA-113418 Formation of the Early Elongation Complex
Reactome:R-BTA-72086 mRNA Capping
Reactome:R-BTA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Reactome:R-DDI-5696395 Formation of Incision Complex in GG-NER
Reactome:R-DDI-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome:R-DDI-73864 RNA Polymerase I Transcription
Reactome:R-DDI-212436 Generic Transcription Pathway
Reactome:R-DDI-674695 RNA Polymerase II Pre-transcription Events
Reactome:R-DDI-73776 RNA Polymerase II Promoter Escape
Reactome:R-DDI-72086 mRNA Capping
Reactome:R-GGA-353377 DNA repair
Reactome:R-GGA-73894 DNA Repair
Reactome:R-GGA-5693607 Processing of DNA double-strand break ends
Reactome:R-GGA-5693537 Resolution of D-Loop Structures
Reactome:R-HSA-1852241 Organelle biogenesis and maintenance
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-73894 DNA Repair
Reactome:R-HSA-5693607 Processing of DNA double-strand break ends
Reactome:R-HSA-5693537 Resolution of D-Loop Structures
Reactome:R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Reactome:R-HSA-8953897 Cellular responses to stimuli
Reactome:R-HSA-5663205 Infectious disease
Reactome:R-HSA-167162 RNA Polymerase II HIV Promoter Escape
Reactome:R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
Reactome:R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
Reactome:R-HSA-73854 RNA Polymerase I Promoter Clearance
Reactome:R-HSA-674695 RNA Polymerase II Pre-transcription Events
Reactome:R-HSA-73776 RNA Polymerase II Promoter Escape
Reactome:R-HSA-112382 Formation of RNA Pol II elongation complex
Reactome:R-HSA-72086 mRNA Capping
Reactome:R-MMU-73886 Chromosome Maintenance
Reactome:R-MMU-180786 Extension of Telomeres
Reactome:R-MMU-69306 DNA Replication
Reactome:R-MMU-5693532 DNA Double-Strand Break Repair
Reactome:R-MMU-5693538 Homology Directed Repair
Reactome:R-MMU-5693579 Homologous DNA Pairing and Strand Exchange
Reactome:R-MMU-5696398 Nucleotide Excision Repair
Reactome:R-MMU-5696400 Dual Incision in GG-NER
Reactome:R-MMU-6782135 Dual incision in TC-NER
Reactome:R-MMU-73854 RNA Polymerase I Promoter Clearance
Reactome:R-MMU-75953 RNA Polymerase II Transcription Initiation
Reactome:R-MMU-113418 Formation of the Early Elongation Complex
Reactome:R-RNO-171319 Telomere Extension By Telomerase
Reactome:R-SCE-73894 DNA Repair
Reactome:R-SCE-6781823 Formation of TC-NER Pre-Incision Complex
Reactome:R-SCE-74160 Gene expression (Transcription)
Reactome:R-SCE-73857 RNA Polymerase II Transcription
Reactome:R-SCE-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
Reactome:R-SCE-77075 RNA Pol II CTD phosphorylation and interaction with CE
Reactome:R-SPO-69190 DNA strand elongation
Reactome:R-SPO-69183 Processive synthesis on the lagging strand
Reactome:R-SPO-69278 Cell Cycle, Mitotic
Reactome:R-SPO-73857 RNA Polymerase II Transcription
Reactome:R-SPO-674695 RNA Polymerase II Pre-transcription Events
Reactome:R-SPO-73776 RNA Polymerase II Promoter Escape
Reactome:R-SPO-73894 DNA Repair
Reactome:R-SPO-5696398 Nucleotide Excision Repair
Reactome:R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
WikiPathways:WP4016 DNA IR-damage and cellular response via ATR