EC: 4.3.1.4

formimidoyltetrahydrofolate cyclodeaminase (5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming))

enzyme lambda metabolic reaction experiment
uniprot:P53603 [K+]

5_Formiminotetrahydrofolate -> 5,10_Methenyltetrahydrofolate + NH3		 (( (Vmax * M) ) / (Km + M)) buffer: 0.1 M triethanolamine sulfate, 2 mM mercaptoethanol
PH: 6.7
Temperature: 25
uniprot:P53603 [K+]

5_Formiminotetrahydrofolate -> NH3 + 5,10_Methenyltetrahydrofolate		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M triethanolamine sulfate, 2 mM mercaptoethanol
PH: 7.2
Temperature: 25
uniprot:P53603 [NH4+]

5_Formiminotetrahydrofolate -> NH3 + 5,10_Methenyltetrahydrofolate		 (( (Vmax * M) ) / (Km + M)) buffer: 0.1 M triethanolamine sulfate, 2 mM mercaptoethanol
PH: 6.7
Temperature: 25
uniprot:P53603 [formimidoyltetrahydrofolate cyclodeaminase(Enzyme) wildtype]

5_Formiminotetrahydrofolate -> NH3 + 5,10_Methenyltetrahydrofolate		 (( (Vmax * A) ) / (Km + A)) buffer: 0.1 M triethanolamine sulfate, 2 mM mercaptoethanol
PH: 7.2
Temperature: 25

Pathways

pathway id name
BioCyc:HUMAN_PWY-5030 histidine degradation
BioCyc:MOUSE_PWY-5030 histidine degradation III
Reactome:R-MMU-1430728 Metabolism
Reactome:R-DDI-71291 Amino acid and derivative metabolism
Reactome:R-HSA-70921 Histidine catabolism
Reactome:R-MMU-70921 Histidine catabolism
Reactome:R-RNO-70921 Histidine catabolism
Reactome:R-DDI-70921 Histidine catabolism
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-RNO-1430728 Metabolism
Reactome:R-RNO-71291 Amino acid and derivative metabolism
Reactome:R-DDI-1430728 Metabolism
Reactome:R-HSA-1430728 Metabolism
WikiPathways:WP4259 Disorders of folate metabolism and transport
PathBank:SMP0000432 Methotrexate Action Pathway
PathBank:SMP0000543 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0120656 Folate Malabsorption, Hereditary
PathBank:SMP0120493 Histidinemia
PathBank:SMP0000044 Histidine Metabolism
PathBank:SMP0000191 Histidinemia
PathBank:SMP0063632 Histidine Metabolism
PathBank:SMP0120522 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0000053 Folate Metabolism
PathBank:SMP0000724 Folate Malabsorption, Hereditary
PathBank:SMP0000801 Folate Metabolism