EC: 2.1.2.1

glycine hydroxymethyltransferase (5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase)

enzyme lambda metabolic reaction experiment
- [L-Threonine]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [L-Methionine]

5,6,7,8_Tetrahydrofolate + L_Serine -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [Spermidine]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [Spermine]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [NAD+]

5,6,7,8_Tetrahydrofolate + L_Serine -> H2O + Glycine + 5,10_Methylenetetrahydrofolate		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [NAD+]

5,6,7,8_Tetrahydrofolate + L_Serine -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [NADP+]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [AMP]

5,6,7,8_Tetrahydrofolate + L_Serine -> H2O + Glycine + 5,10_Methylenetetrahydrofolate		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [L-Lysine]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [L-Lysine]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [Thiamine monophosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [Thiamine monophosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [ATP]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [glycine hydroxymethyltransferase(Enzyme) wildtype]

L_Serine + 5,6,7,8_Tetrahydrofolate -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (Vmax * A) ) / (Km_1 + A)) buffer: 50 mM Tris-HCl, 10 mM 2-mercaptoethanol
PH: 8.5
Temperature: 25
- [glycine hydroxymethyltransferase(Enzyme) wildtype]

5,6,7,8_Tetrahydrofolate + L_Serine -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (Vmax * B) ) / (Km + B)) buffer: 50 mM Tris-HCl, 10 mM 2-mercaptoethanol
PH: 8.5
Temperature: 25
- [Pyridoxal phosphate]

5,6,7,8_Tetrahydrofolate + L_Serine -> H2O + Glycine + 5,10_Methylenetetrahydrofolate		 (( (Vmax * S) ) / (Km + S)) buffer: 0.4 M potassium phosphate, 2 mM EDTA, 1.0 mM 2-mercaptoethanol, 1.8 mM dithiothreitol, 400 mM NADP, 40 µg/ml 5,10-CH2-H4folate dehydrogenase
PH: 7.4
Temperature: 37
- [NAD+]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [NADH]

L_Serine + 5,6,7,8_Tetrahydrofolate -> H2O + Glycine + 5,10_Methylenetetrahydrofolate		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [NADH]

5,6,7,8_Tetrahydrofolate + L_Serine -> Glycine + 5,10_Methylenetetrahydrofolate + H2O		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [NADH]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [NADH]

5,6,7,8_Tetrahydrofolate + L_Serine -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (Vmax * A) ) / (Km + A)) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [glycine hydroxymethyltransferase(Enzyme) wildtype]

L_Serine + 5,6,7,8_Tetrahydrofolate -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
- [glycine hydroxymethyltransferase(Enzyme) wildtype]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (Vmax * (A ^ n)) ) / (( (S_half ^ n) ) + (A ^ n))) buffer: 20 mM potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 0.1 mM pyridoxal 5'-phosphate, 1.8 mM DTT
PH: 7.4
Temperature: 37
uniprot:P0A825 [glycine hydroxymethyltransferase(Enzyme) wildtype]

5,6,7,8_Tetrahydrofolate + L_Serine -> Glycine + 5,10_Methylenetetrahydrofolate + H2O		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM sodium Hepes, 0.2 mM DTT, 0.1 mM EDTA
PH: 7.2
Temperature: 30
uniprot:P0A825 [glycine hydroxymethyltransferase(Enzyme) mutant R235Q]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM sodium Hepes, 0.2 mM DTT, 0.1 mM EDTA
PH: 7.2
Temperature: 30
uniprot:P0A825 [glycine hydroxymethyltransferase(Enzyme) mutant R235L]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + 5,10_Methylenetetrahydrofolate + H2O		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM sodium Hepes, 0.2 mM DTT, 0.1 mM EDTA
PH: 7.2
Temperature: 30
uniprot:P0A825 [glycine hydroxymethyltransferase(Enzyme) mutant R235K]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM sodium Hepes, 0.2 mM DTT, 0.1 mM EDTA
PH: 7.2
Temperature: 30
uniprot:P0A825 [glycine hydroxymethyltransferase(Enzyme) mutant Y55F]

L_Serine + 5,6,7,8_Tetrahydrofolate -> H2O + Glycine + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM sodium Hepes, 0.2 mM DTT, 0.1 mM EDTA
PH: 7.2
Temperature: 30
uniprot:P0A825 [glycine hydroxymethyltransferase(Enzyme) mutant Y55F]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM sodium Hepes, 0.2 mM DTT, 0.1 mM EDTA
PH: 7.2
Temperature: 30
uniprot:P0A825 [glycine hydroxymethyltransferase(Enzyme) wildtype]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + 5,10_Methylenetetrahydrofolate + H2O		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM sodium Hepes, 0.2 mM DTT, 0.1 mM EDTA
PH: 7.2
Temperature: 30
uniprot:P34897 [Pyridoxal phosphate]

5,6,7,8_Tetrahydrofolate + L_Serine -> H2O + Glycine + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM sodium HEPES, 0.2 mM dithiothreitol, 0.1 mM EDTA
PH: 7.2
Temperature: 20
uniprot:P34897 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + 5,10_Methylenetetrahydrofolate + H2O		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM sodium HEPES, 0.2 mM dithiothreitol, 0.1 mM EDTA
PH: 7.2
Temperature: 20
uniprot:P34896 [Pyridoxal phosphate]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM sodium HEPES, 0.2 mM dithiothreitol, 0.1 mM EDTA
PH: 7.2
Temperature: 20
uniprot:P0A825 [glycine hydroxymethyltransferase(Enzyme) mutant R235L]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM sodium Hepes, 0.2 mM DTT, 0.1 mM EDTA
PH: 7.2
Temperature: 30
uniprot:P0A825 [glycine hydroxymethyltransferase(Enzyme) mutant R235Q]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM sodium Hepes, 0.2 mM DTT, 0.1 mM EDTA
PH: 7.2
Temperature: 30
uniprot:P0A825 [glycine hydroxymethyltransferase(Enzyme) mutant R235K]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + 5,10_Methylenetetrahydrofolate + H2O		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 50 mM sodium Hepes, 0.2 mM DTT, 0.1 mM EDTA
PH: 7.2
Temperature: 30
uniprot:P34896 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (( (( (E * kcat) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 50 mM HEPES, 1 mM DTT, 0.5 mM EDTA, 250 µM NADP+, 10 µM 5,10-Methylenetetrahydrofolate dehydrogenase
PH: 7
Temperature: 25
uniprot:P34896 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (( (( (E * kcat) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 50 mM potassium phosphate, 1 mM DTT, 0.5 mM EDTA, 250 µM NADP+, 10 µM 5,10-Methylenetetrahydrofolate dehydrogenase
PH: 7
Temperature: 25
uniprot:P34896 [Pyridoxal phosphate]

D_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (( (( (E * kcat) ) * A) ) * B) ) / (( (( (( (Ki_A * Km_B) ) + (Km_A * B)) ) + (Km_B * A)) ) + (A * B))) buffer: 50 mM HEPES, 1 mM DTT, 0.5 mM EDTA, 250 µM NADP+, 10 µM 5,10-Methylenetetrahydrofolate dehydrogenase
PH: 7
Temperature: 25
uniprot:A0A1V0CMF9 [Pyridoxal phosphate]

DL_beta_Phenylserine -> Glycine + Benzaldehyde		 (( (Vmax * S) ) / (Km + S)) buffer: sodium phosphate, 1 mM Na2EDTA, 25 mM sodium sulphate
PH: 7
Temperature: 37
uniprot:A0A1V0CMF9 [Pyridoxal phosphate]

DL_beta_Phenylserine -> Benzaldehyde + Glycine		 (( (Vmax * S) ) / (Km + S)) buffer: sodium phosphate, 1 mM Na2EDTA, 25 mM sodium sulphate
PH: 7
Temperature: 37
uniprot:A5K8L9 [Pyridoxal phosphate]

5,6,7,8_Tetrahydrofolate + L_Serine -> Glycine + 5,10_Methylenetetrahydrofolate + H2O		 (E / (( (( (( (1 / kcat) ) + (( (Km_A / kcat) ) / A)) ) + (( (Km_B / kcat) ) / B)) ) + (( (( (Km_A * Km_B) ) / kcat) ) / (A * B)))) buffer: 50 mM HEPES, 1 mM dithiothreitol, 0.5 mM EDTA, 150 µM NADH, 3 µM 5,10‐methylenetetrahydrofolate reductase
PH: 7
Temperature: 25
uniprot:Q5U3Z7 [Pyridoxal phosphate]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 20 mM Phosphate
PH: 7.2
Temperature: 37
uniprot:Q6TXG7 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 20 mM Phosphate
PH: 7.2
Temperature: 37
uniprot:Q5U3Z7 [Pyridoxal phosphate]

L_allo_Threonine -> Glycine + Acetaldehyde		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 20 mM Phosphate
PH: 7.2
Temperature: 37
uniprot:Q6TXG7 [Pyridoxal phosphate]

L_allo_Threonine -> Acetaldehyde + Glycine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 20 mM Phosphate
PH: 7.2
Temperature: 37
- [glycine hydroxymethyltransferase(Enzyme) wildtype]

5,6,7,8_Tetrahydrofolate + L_Serine -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (( (E * kcat) ) * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.4 M potassium phosphate, 1 mM 2-mercaptoethanol, 10 mM EDTA, 0.2 mM pyridoxal 5'-phosphate, 1.8 mM dithiothreitol
PH: 7.4
Temperature: 37
- [glycine hydroxymethyltransferase(Enzyme) wildtype]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 0.4 M potassium phosphate, 1 mM 2-mercaptoethanol, 10 mM EDTA, 0.2 mM pyridoxal 5'-phosphate, 1.8 mM dithiothreitol
PH: 7.4
Temperature: 37
- [NAD+]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.4 M potassium phosphate, 1 mM 2-mercaptoethanol, 10 mM EDTA, 0.2 mM pyridoxal 5'-phosphate, 1.8 mM dithiothreitol
PH: 7.4
Temperature: 37
- [NADH]

5,6,7,8_Tetrahydrofolate + L_Serine -> H2O + Glycine + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.4 M potassium phosphate, 1 mM 2-mercaptoethanol, 10 mM EDTA, 0.2 mM pyridoxal 5'-phosphate, 1.8 mM dithiothreitol
PH: 7.4
Temperature: 37
- [NADPH]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (( (E * kcat) ) * (S ^ n)) ) / (( (S_half ^ n) ) + (S ^ n))) buffer: 0.4 M potassium phosphate, 1 mM 2-mercaptoethanol, 10 mM EDTA, 0.2 mM pyridoxal 5'-phosphate, 1.8 mM dithiothreitol
PH: 7.4
Temperature: 37
- [glycine hydroxymethyltransferase(Enzyme) wildtype]

5,6,7,8_Tetrahydrofolate + L_Serine -> Glycine + 5,10_Methylenetetrahydrofolate + H2O		 (( (( (E * kcat) ) * (S ^ n)) ) / (( (( (S_half ^ n) ) * (1 + (I / Ki))) ) + (( (S ^ n) ) * (1 + (I / Ki))))) buffer: 0.4 M potassium phosphate, 1 mM 2-mercaptoethanol, 10 mM EDTA, 0.2 mM pyridoxal 5'-phosphate, 1.8 mM dithiothreitol
PH: 7.4
Temperature: 37
- [Cycloserine]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (( (E * kcat) ) * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 0.4 M potassium phosphate, 1 mM 2-mercaptoethanol, 10 mM EDTA, 0.2 mM pyridoxal 5'-phosphate, 1.8 mM dithiothreitol
PH: 7.4
Temperature: 37
- [glycine hydroxymethyltransferase(Enzyme) wildtype]

5,6,7,8_Tetrahydrofolate + L_Serine -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * A) ) / (( (Km * (1 + (I / Ki))) ) + A)) buffer: 0.4 M potassium phosphate, 1 mM 2-mercaptoethanol, 10 mM EDTA, 0.2 mM pyridoxal 5'-phosphate, 1.8 mM dithiothreitol
PH: 7.4
Temperature: 37
uniprot:Q5U3Z7 [glycine hydroxymethyltransferase(Enzyme) wildtype isoenzyme Shmt2]

5,10_Methylenetetrahydrofolate + H2O + Glycine -> 5,6,7,8_Tetrahydrofolate + L_Serine		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Potassium phosphate
PH: 7.3
Temperature: 37
uniprot:Q5U3Z7 [glycine hydroxymethyltransferase(Enzyme) wildtype isoenzyme Shmt2]

5,6,7,8_Tetrahydrofolate + L_Serine -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Potassium phosphate
PH: 7.3
Temperature: 37
uniprot:Q5U3Z7 [glycine hydroxymethyltransferase(Enzyme) wildtype isoenzyme Shmt2]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Potassium phosphate
PH: 7.3
Temperature: 37
uniprot:Q5U3Z7 [glycine hydroxymethyltransferase(Enzyme) wildtype isoenzyme Shmt2]

Glycine + H2O + 5,10_Methylenetetrahydrofolate -> 5,6,7,8_Tetrahydrofolate + L_Serine		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Potassium phosphate
PH: 7.3
Temperature: 37
uniprot:Q6TXG7 [glycine hydroxymethyltransferase(Enzyme) wildtype isoenzyme Shmt1]

H2O + Glycine + 5,10_Methylenetetrahydrofolate -> 5,6,7,8_Tetrahydrofolate + L_Serine		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Potassium phosphate
PH: 7.3
Temperature: 37
uniprot:Q6TXG7 [glycine hydroxymethyltransferase(Enzyme) wildtype isoenzyme Shmt1]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Potassium phosphate
PH: 7.3
Temperature: 37
uniprot:Q6TXG7 [glycine hydroxymethyltransferase(Enzyme) wildtype isoenzyme Shmt1]

Glycine + 5,10_Methylenetetrahydrofolate + H2O -> L_Serine + 5,6,7,8_Tetrahydrofolate		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Potassium phosphate
PH: 7.3
Temperature: 37
uniprot:Q6TXG7 [glycine hydroxymethyltransferase(Enzyme) wildtype isoenzyme Shmt1]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (Vmax * S) ) / (Km + S)) buffer: 100 mM Potassium phosphate
PH: 7.3
Temperature: 37
uniprot:P35623 [Pyridoxal phosphate]

5,6,7,8_Tetrahydrofolate + L_Serine -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 0.4 M potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 1.8 mM dithiothreitol
PH: 7.4
Temperature: 37
uniprot:P35623 [Pyridoxal phosphate]

L_allo_Threonine -> Glycine + Acetaldehyde		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 0.01 M phosphate, excess alcohol dehydrogenase, 0.17 mM NADH
PH: 7.4
Temperature: 37
uniprot:Q7SIB6 [Pyridoxal phosphate]

L_allo_Threonine -> Glycine + Acetaldehyde		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 0.01 M phosphate, excess alcohol dehydrogenase, 0.17 mM NADH
PH: 7.4
Temperature: 37
uniprot:Q7SIB6 [Pyridoxal phosphate]

L_allo_Threonine -> Glycine + Acetaldehyde		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 0.01 M phosphate, excess alcohol dehydrogenase, 0.17 mM NADH
PH: 7.4
Temperature: 37
uniprot:P0A825 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 0.05 M potassium phosphate, 2.5 mM mercaptoethanol
PH: 7.3
Temperature: 37
uniprot:P0A825 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (Vmax * B) ) / (Km + B)) buffer: 0.05 M potassium phosphate, 2.5 mM mercaptoethanol
PH: 7.3
Temperature: 37
uniprot:P0A825 [Pyridoxal phosphate]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Na-Hepes, 200 µM dithiothreitol, 100 µM EDTA
PH: 7.2
Temperature: 20
uniprot:P0A825 [Pyridoxal phosphate]

5,6,7,8_Tetrahydrofolate + L_Serine -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Na-Hepes, 200 µM dithiothreitol, 100 µM EDTA
PH: 7.2
Temperature: 20
uniprot:P0A825 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Na-Hepes, 200 µM dithiothreitol, 100 µM EDTA
PH: 7.2
Temperature: 20
uniprot:P0A825 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Na-Hepes, 200 µM dithiothreitol, 100 µM EDTA
PH: 7.2
Temperature: 20
uniprot:P0A825 [Pyridoxal phosphate]

L_threo_3_Phenylserine -> Benzaldehyde + Glycine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Na-Hepes, 200 µM dithiothreitol, 100 µM EDTA
PH: 7.2
Temperature: 20
uniprot:P0A825 [Pyridoxal phosphate]

L_threo_3_Phenylserine -> Glycine + Benzaldehyde		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Na-Hepes, 200 µM dithiothreitol, 100 µM EDTA
PH: 7.2
Temperature: 20
uniprot:P0A825 [Pyridoxal phosphate]

L_threo_3_Phenylserine -> Glycine + Benzaldehyde		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Na-Hepes, 200 µM dithiothreitol, 100 µM EDTA
PH: 7.2
Temperature: 20
uniprot:P0A825 [Pyridoxal phosphate]

L_threo_3_Phenylserine -> Glycine + Benzaldehyde		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Na-Hepes, 200 µM dithiothreitol, 100 µM EDTA
PH: 7.2
Temperature: 20
uniprot:P0A825 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + 5,10_Methylenetetrahydrofolate + H2O		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Na-Hepes, 200 µM dithiothreitol, 100 µM EDTA
PH: 7.2
Temperature: 20
uniprot:P0A825 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Na-Hepes, 200 µM dithiothreitol, 100 µM EDTA
PH: 7.2
Temperature: 20
uniprot:P0A825 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Na-Hepes, 200 µM dithiothreitol, 100 µM EDTA
PH: 7.2
Temperature: 20
uniprot:P0A825 [Pyridoxal phosphate]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 50 mM Na-Hepes, 200 µM dithiothreitol, 100 µM EDTA
PH: 7.2
Temperature: 20
uniprot:Q8I566 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> H2O + Glycine + 5,10_Methylenetetrahydrofolate		 (E / (( (( (( (1 / kcat) ) + (( (Km_A / kcat) ) / A)) ) + (( (Km_B / kcat) ) / B)) ) + (( (( (Km_A * Km_B) ) / kcat) ) / (A * B)))) buffer: 50 mM HEPES, 0.5 mM EDTA, 1 mM DTT, 3 µM His6-MTHFR (5,10-methylenetetrahydrofolate reductase), 100 µM NADH
PH: 7.45
Temperature: 25
uniprot:Q8I566 [Glycine]

L_Serine + 5,6,7,8_Tetrahydrofolate -> H2O + Glycine + 5,10_Methylenetetrahydrofolate		 (( (Vmax * B) ) / (( (Km_B * (1 + (I / Kis))) ) + (B * (1 + (I / Kii))))) buffer: 50 mM HEPES, 0.5 mM EDTA, 1 mM DTT, 3 µM His6-MTHFR (5,10-methylenetetrahydrofolate reductase), 100 µM NADH
PH: 7.45
Temperature: 25
uniprot:Q8I566 [Glycine]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + 5,10_Methylenetetrahydrofolate + H2O		 (( (Vmax * A) ) / (( (Km_A * (1 + (I / Kis))) ) + A)) buffer: 50 mM HEPES, 0.5 mM EDTA, 1 mM DTT, 3 µM His6-MTHFR (5,10-methylenetetrahydrofolate reductase), 100 µM NADH
PH: 7.45
Temperature: 25
uniprot:Q8I566 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> H2O + Glycine + 5,10_Methylenetetrahydrofolate		 (E / (( (( (( (1 / kcat) ) + (( (Km_A / kcat) ) / A)) ) + (( (Km_B / kcat) ) / B)) ) + (( (( (Km_A * Km_B) ) / kcat) ) / (A * B)))) buffer: 50 mM sodium phosphate, 0.5 mM EDTA, 1 mM DTT, 3 µM His6-MTHFR (5,10-methylenetetrahydrofolate reductase), 100 µM NADH
PH: 7
Temperature: 25
uniprot:Q8I566 [Pyridoxal phosphate]

D_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM HEPES, 0.5 mM EDTA, 1 mM DTT, 3 µM His6-MTHFR (5,10-methylenetetrahydrofolate reductase), 100 µM NADH
PH: 8
Temperature: 25
uniprot:Q7SIB6 [Pyridoxal phosphate]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 0.4 M potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 1.8 mM dithiothreitol
PH: 7.4
Temperature: 37
uniprot:Q7SIB6 [Pyridoxal phosphate]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 0.4 M potassium phosphate, 1 mM 2-mercaptoethanol, 1 mM EDTA, 1.8 mM dithiothreitol
PH: 7.4
Temperature: 37
uniprot:P07511 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 20 mM potassium phosphate, 5 mM 2-mercaptoethanol, 100 mM NADP+, 50 µg/ml C1-THF synthase
PH: 7.3
Temperature: 30
uniprot:P07511 [Pyridoxal phosphate]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (( (E * kcat) ) * B) ) / (Km + B)) buffer: 20 mM potassium phosphate, 5 mM 2-mercaptoethanol, 100 mM NADP+, 50 µg/ml C1-THF synthase
PH: 7.3
Temperature: 30
uniprot:P07511 [glycine hydroxymethyltransferase(Enzyme) wildtype]

L_allo_Threonine -> Glycine + Acetaldehyde		 (( (( (E * kcat) ) * S) ) / (Km + S)) buffer: 20 mM potassium phosphate, excess NADH, excess alcohol dehydrogenase
PH: 7.3
Temperature: 30
uniprot:Q94C74 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT2 (aa 41-517)]

5,6,7,8_Tetrahydrofolate + L_Serine -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (( (E * kcat) ) * A) ) / (A + (Km * (1 + (A / Ki))))) buffer: 20 mM phosphate
PH: 8.5
Temperature: 30
uniprot:Q94C74 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT2 (aa 41-517)]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * A) ) / (A + (Km * (1 + (A / Ki))))) buffer: 20 mM phosphate
PH: 7
Temperature: 30
uniprot:Q94C74 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT2 (aa 41-517)]

L_Serine + 5,6,7,8_Tetrahydrofolate -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (( (E * kcat) ) * A) ) / (A + (Km * (1 + (A / Ki))))) buffer: 20 mM phosphate
PH: 8
Temperature: 30
uniprot:Q94C74 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT2 (aa 41-517)]

L_Serine + 5,6,7,8_Tetrahydrofolate -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 20 mM phosphate
PH: 8.5
Temperature: 30
uniprot:Q94C74 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT2 (aa 41-517)]

5,6,7,8_Tetrahydrofolate + L_Serine -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 20 mM phosphate
PH: 7
Temperature: 30
uniprot:Q94C74 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT2 (aa 41-517)]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 20 mM phosphate
PH: 8
Temperature: 30
uniprot:Q94C74 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT2 (aa 41-517)]

5,6,7,8_Tetrahydrofolate + L_Serine -> Glycine + 5,10_Methylenetetrahydrofolate + H2O		 (( (( (E * kcat) ) * A) ) / (A + (Km * (1 + (A / Ki))))) buffer: 20 mM phosphate
PH: 6.5
Temperature: 30
uniprot:Q94C74 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT2 (aa 41-517)]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + H2O + Glycine		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 20 mM phosphate
PH: 6.5
Temperature: 30
uniprot:O23254 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT4]

L_Serine + 5,6,7,8_Tetrahydrofolate -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (( (E * kcat) ) * A) ) / (A + (Km * (1 + (A / Ki))))) buffer: 50 mM HEPES, 50 mM MES, 50 mM CHES
PH: 9.5
Temperature: 30
uniprot:O23254 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT4]

5,6,7,8_Tetrahydrofolate + L_Serine -> H2O + Glycine + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * A) ) / (A + (Km * (1 + (A / Ki))))) buffer: 20 mM phosphate
PH: 8.5
Temperature: 30
uniprot:O23254 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT4]

5,6,7,8_Tetrahydrofolate + L_Serine -> Glycine + 5,10_Methylenetetrahydrofolate + H2O		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM HEPES, 50 mM MES, 50 mM CHES
PH: 9.5
Temperature: 30
uniprot:Q94C74 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT2 (aa 41-517)]

L_Serine + 5,6,7,8_Tetrahydrofolate -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (( (E * kcat) ) * A) ) / (A + (Km * (1 + (A / Ki))))) buffer: 50 mM HEPES, 50 mM MES, 50 mM CHES
PH: 9.5
Temperature: 30
uniprot:O23254 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT4]

5,6,7,8_Tetrahydrofolate + L_Serine -> H2O + 5,10_Methylenetetrahydrofolate + Glycine		 (( (( (E * kcat) ) * A) ) / (A + (Km * (1 + (A / Ki))))) buffer: 20 mM phosphate
PH: 7
Temperature: 30
uniprot:O23254 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT4]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * A) ) / (A + (Km * (1 + (A / Ki))))) buffer: 20 mM phosphate
PH: 8
Temperature: 30
uniprot:O23254 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT4]

5,6,7,8_Tetrahydrofolate + L_Serine -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * A) ) / (A + (Km * (1 + (A / Ki))))) buffer: 20 mM phosphate
PH: 6.5
Temperature: 30
uniprot:Q94C74 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT2 (aa 41-517)]

L_Serine + 5,6,7,8_Tetrahydrofolate -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 50 mM HEPES, 50 mM MES, 50 mM CHES
PH: 9.5
Temperature: 30
uniprot:O23254 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT4]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 20 mM phosphate
PH: 7
Temperature: 30
uniprot:O23254 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT4]

5,6,7,8_Tetrahydrofolate + L_Serine -> Glycine + H2O + 5,10_Methylenetetrahydrofolate		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 20 mM phosphate
PH: 8.5
Temperature: 30
uniprot:O23254 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT4]

5,6,7,8_Tetrahydrofolate + L_Serine -> Glycine + 5,10_Methylenetetrahydrofolate + H2O		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 20 mM phosphate
PH: 6.5
Temperature: 30
uniprot:O23254 [glycine hydroxymethyltransferase(Enzyme) wildtype AtSHMT4]

5,6,7,8_Tetrahydrofolate + L_Serine -> 5,10_Methylenetetrahydrofolate + Glycine + H2O		 (( (( (E * kcat) ) * A) ) / (Km + A)) buffer: 20 mM phosphate
PH: 8
Temperature: 30

Pathways

pathway id name
BioCyc:HUMAN_PWY66-414 superpathway of choline degradation to L-serine
BioCyc:HUMAN_PWY-2161 folate polyglutamylation
BioCyc:META_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:META_PWY-3841 folate transformations II
BioCyc:META_PWY-2201 folate transformations I
BioCyc:META_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I
BioCyc:ECO_PWY-2161 folate polyglutamylation
BioCyc:YEAST_PWY3O-230 serine biosynthesis from glyoxylate
BioCyc:ARA_PWY-3841 folate transformations II
BioCyc:ARA_PWY-2161 folate polyglutamylation
BioCyc:VCHO_PWY-3841 folate transformations II
BioCyc:VCHO_PWY-2161 folate polyglutamylation
BioCyc:VCHO_GLYSYN-PWY glycine biosynthesis I
BioCyc:MTBCDC1551_GLYSYN-PWY glycine biosynthesis I
BioCyc:MTBCDC1551_PWY-2201 folate transformations I
BioCyc:HPY_PWY-2161 folate polyglutamylation
BioCyc:CAULO_PWY-2201 folate transformations I
BioCyc:ANTHRA_PWY-2161 folate polyglutamylation
BioCyc:AGRO_GLYSYN-PWY glycine biosynthesis I
BioCyc:BSUB_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:SYNEL_PWY-181 photorespiration
BioCyc:BTHE_SER-GLYSYN-PWY superpathway of serine and glycine biosynthesis I
BioCyc:BTHE_PWY-2201 folate transformations I
BioCyc:HUMAN_GLYSYN-PWY glycine/serine biosynthesis
BioCyc:META_GLYSYN-PWY glycine biosynthesis I
BioCyc:META_PWY-2161 folate polyglutamylation
BioCyc:META_PWY-1622 formaldehyde assimilation I (serine pathway)
BioCyc:META_PWY-181 photorespiration
BioCyc:YEAST_SER-GLYSYN-PWY superpathway of serine and glycine biosynthesis I
BioCyc:YEAST_PWY3O-697 folate interconversions
BioCyc:VCHO_PWY-2201 folate transformations I
BioCyc:VCHO_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:VCHO_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I
BioCyc:MTBH37RV_GLYSYN-PWY glycine biosynthesis I
BioCyc:MTBCDC1551_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:MTBCDC1551_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I
BioCyc:MTBCDC1551_PWY-2161 folate polyglutamylation
BioCyc:ECOO157_GLYSYN-PWY glycine biosynthesis I
BioCyc:CAULO_SER-GLYSYN-PWY superpathway of serine and glycine biosynthesis I
BioCyc:CAULO_GLYSYN-PWY glycine biosynthesis I
BioCyc:ANTHRA_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:ANTHRA_GLYSYN-PWY glycine biosynthesis I
BioCyc:AGRO_PWY-2161 folate polyglutamylation
BioCyc:MOUSE_PWY-2161 folate polyglutamylation
BioCyc:MOUSE_PWY-2201 folate transformations I
BioCyc:MOUSE_SER-GLYSYN-PWY superpathway of serine and glycine biosynthesis I
BioCyc:BSUB_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I
BioCyc:BSUB_PWY-2161 folate polyglutamylation
BioCyc:ECOL316407_PWY-2161 folate polyglutamylation
BioCyc:PDIF272563_GLYSYN-PWY glycine biosynthesis I
BioCyc:PDIF272563_PWY-2161 folate polyglutamylation
BioCyc:PDIF272563_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:BTHE_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:CORYNE_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I
BioCyc:CORYNE_PWY-2161 folate polyglutamylation
BioCyc:CORYNE_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:GCF_000013425_PWY-2201 folate transformations I
BioCyc:HUMAN_PWY66-385 dTMP de novo biosynthesis (mitochondrial)
BioCyc:HUMAN_PWY-3661-1 glycine betaine degradation II (mammalian)
BioCyc:ECO_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I
BioCyc:ECO_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:YEAST_PWY-2161 folate polyglutamylation
BioCyc:MTBH37RV_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:HPY_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I
BioCyc:ECOO157_PWY-2201 folate transformations I
BioCyc:ECOO157_SER-GLYSYN-PWY superpathway of serine and glycine biosynthesis I
BioCyc:CAULO_PWY-2161 folate polyglutamylation
BioCyc:CAULO_1CMET2-PWY formylTHF biosynthesis I
BioCyc:CAULO_PWY-3841 folate transformations II
BioCyc:ANTHRA_PWY-1622 formaldehyde assimilation I (serine pathway)
BioCyc:AGRO_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I
BioCyc:MOUSE_PWY3DJ-35778 Serine degradation II
BioCyc:MOUSE_GLYSYN-PWY glycine biosynthesis I
BioCyc:SYNEL_PWY-2161 folate polyglutamylation
BioCyc:SYNEL_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:SYNEL_PWY-2201 folate transformations I
BioCyc:SYNEL_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I
BioCyc:ECOL316407_GLYSYN-PWY glycine biosynthesis I
BioCyc:CORYNE_GLYSYN-PWY glycine biosynthesis I
BioCyc:GCF_000013425_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:GCF_000013425_PWY-2161 folate polyglutamylation
BioCyc:GCF_000013425_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I
BioCyc:GCF_000013425_GLYSYN-PWY glycine biosynthesis I
BioCyc:HUMAN_SER-GLYSYN-PWY serine and glycine biosynthesis
BioCyc:HUMAN_PWY-2201 folate transformations I
BioCyc:META_PWY-3661-1 glycine betaine degradation II (mammalian)
BioCyc:META_PWY-3661 glycine betaine degradation I
BioCyc:ECO_GLYSYN-PWY glycine biosynthesis I
BioCyc:YEAST_PWY66-385 dTMP de novo biosynthesis (mitochondrial)
BioCyc:YEAST_PWY-2201 folate transformations
BioCyc:YEAST_GLYSYN-PWY glycine biosynthesis from serine
BioCyc:ARA_GLYSYN-PWY glycine biosynthesis I
BioCyc:ARA_GLYSYN2-PWY glycine biosynthesis
BioCyc:ARA_PWY-181 photorespiration
BioCyc:MTBH37RV_PWY-2161 folate polyglutamylation
BioCyc:MTBH37RV_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I
BioCyc:HPY_1CMET2-PWY formylTHF biosynthesis I
BioCyc:HPY_GLYSYN-PWY glycine biosynthesis I
BioCyc:ECOO157_PWY-2161 folate polyglutamylation
BioCyc:ECOO157_1CMET2-PWY formylTHF biosynthesis
BioCyc:ANTHRA_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I
BioCyc:ANTHRA_PWY-2201 folate transformations I
BioCyc:AGRO_PWY-2201 folate transformations I
BioCyc:AGRO_1CMET2-PWY N10-formyl-tetrahydrofolate biosynthesis
BioCyc:MOUSE_PWY-3661 glycine betaine degradation
BioCyc:MOUSE_PWY-3841 folate transformations II (plants)
BioCyc:BSUB_PWY-2201 folate transformations I
BioCyc:BSUB_GLYSYN-PWY glycine biosynthesis I
BioCyc:SYNEL_GLYSYN-PWY glycine biosynthesis I
BioCyc:ECOL316407_1CMET2-PWY formylTHF biosynthesis
BioCyc:ECOL316407_SER-GLYSYN-PWY superpathway of serine and glycine biosynthesis I
BioCyc:PDIF272563_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I
BioCyc:PDIF272563_PWY-2201 folate transformations I
BioCyc:BTHE_PWY-2161 folate polyglutamylation
BioCyc:BTHE_GLYSYN-PWY glycine biosynthesis I
PathBank:SMP0000828 Glycine Biosynthesis
PathBank:SMP0001750 One Carbon Pool by Folate
PlantCyc:ARA_GLYSYN2-PWY glycine biosynthesis
PlantCyc:ARA_PWY-2161 folate polyglutamylation
PlantCyc:ARA_PWY-181 photorespiration
PlantCyc:PLANT_PWY-181 photorespiration
PlantCyc:ARA_GLYSYN-PWY glycine biosynthesis I
PlantCyc:ARA_PWY-3841 folate transformations II
PlantCyc:PLANT_PWY-3841 folate transformations II
PlantCyc:PLANT_PWY-2161 folate polyglutamylation
PlantCyc:PLANT_GLYSYN2-PWY glycine biosynthesis
PlantCyc:PLANT_GLYSYN-PWY glycine biosynthesis I
Reactome:R-BTA-1430728 Metabolism
Reactome:R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-MMU-1430728 Metabolism
Reactome:R-MMU-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-SPO-1430728 Metabolism
Reactome:R-BTA-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-CEL-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-HSA-196854 Metabolism of vitamins and cofactors
Reactome:R-HSA-196757 Metabolism of folate and pterines
Reactome:R-MMU-196854 Metabolism of vitamins and cofactors
Reactome:R-MMU-196757 Metabolism of folate and pterines
Reactome:R-SCE-1430728 Metabolism
Reactome:R-SCE-196849 Metabolism of water-soluble vitamins and cofactors
Reactome:R-CEL-71291 Amino acid and derivative metabolism
Reactome:R-CEL-71262 Carnitine synthesis
Reactome:R-HSA-71291 Amino acid and derivative metabolism
Reactome:R-HSA-71262 Carnitine synthesis
Reactome:R-MMU-71291 Amino acid and derivative metabolism
Reactome:R-MMU-71262 Carnitine synthesis
Reactome:R-SPO-196854 Metabolism of vitamins and cofactors
Reactome:R-SPO-196757 Metabolism of folate and pterines
Reactome:R-BTA-196854 Metabolism of vitamins and cofactors
Reactome:R-BTA-196757 Metabolism of folate and pterines
Reactome:R-CEL-1430728 Metabolism
Reactome:R-CEL-196854 Metabolism of vitamins and cofactors
Reactome:R-CEL-196757 Metabolism of folate and pterines
Reactome:R-HSA-1430728 Metabolism
Reactome:R-SCE-196854 Metabolism of vitamins and cofactors
Reactome:R-SCE-196757 Metabolism of folate and pterines
Reactome:R-SPO-196849 Metabolism of water-soluble vitamins and cofactors
WikiPathways:WP4688 Serine metabolism
WikiPathways:WP5312 Metabolic pathways of fibroblasts
WikiPathways:WP4259 Disorders of folate metabolism and transport
PathBank:SMP0000177 Cystathionine beta-Synthase Deficiency
PathBank:SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)
PathBank:SMP0000242 Dimethylglycine Dehydrogenase Deficiency
PathBank:SMP0000223 Non-Ketotic Hyperglycinemia
PathBank:SMP0000484 Dimethylglycine Dehydrogenase Deficiency
PathBank:SMP0002313 Sarcosine Oncometabolite Pathway
PathBank:SMP0120653 3-Phosphoglycerate Dehydrogenase Deficiency
PathBank:SMP0120471 Cystathionine beta-Synthase Deficiency
PathBank:SMP0120475 Dimethylglycine Dehydrogenase Deficiency
PathBank:SMP0120487 Glycine N-Methyltransferase Deficiency
PathBank:SMP0120519 Methionine Adenosyltransferase Deficiency
PathBank:SMP0120527 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0000004 Glycine and Serine Metabolism
PathBank:SMP0000033 Methionine Metabolism
PathBank:SMP0000222 Glycine N-Methyltransferase Deficiency
PathBank:SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency
PathBank:SMP0002323 Serine Metabolism
PathBank:SMP0002428 Glycine Metabolism
PathBank:SMP0087245 Glycine and Serine Metabolism
PathBank:SMP0063637 Methionine Metabolism
PathBank:SMP0108762 Sarcosine Oncometabolite Pathway
PathBank:SMP0120521 Sarcosinemia
PathBank:SMP0120634 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
PathBank:SMP0000465 Carnitine Synthesis
PathBank:SMP0000341 Hypermethioninemia
PathBank:SMP0000221 Methionine Adenosyltransferase Deficiency
PathBank:SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
PathBank:SMP0000485 Hyperglycinemia, Non-Ketotic
PathBank:SMP0002320 Glycine Metabolism
PathBank:SMP0002443 Serine Metabolism
PathBank:SMP0120474 Dihydropyrimidine Dehydrogenase Deficiency (DHPD)
PathBank:SMP0120498 Hypermethioninemia
PathBank:SMP0120534 Non-Ketotic Hyperglycinemia
PathBank:SMP0120550 Hyperglycinemia, Non-Ketotic
PathBank:SMP0000214 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency
PathBank:SMP0000244 Sarcosinemia
PathBank:SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
PathBank:SMP0012063 Folate Polyglutamylation
PathBank:SMP0063605 Carnitine Synthesis
PathBank:SMP0063626 Glycine and Serine Metabolism